{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:25:19Z","timestamp":1778030719142,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>\n                    The exact mechanism underlying chronic masseter muscle pain, a conspicuous symptom in temporomandibular disorder, remains unclear. We investigated whether expression of P2X\n                    <jats:sub>3<\/jats:sub>\n                    receptor (P2X\n                    <jats:sub>3<\/jats:sub>\n                    R) is involved in mechanical hyperalgesia after contraction of masseter muscle (CMM). As compared with sham rats, the head-withdrawal threshold (HWT) to mechanical pressure stimulation of masseter muscle (MM) (but not after similar stimulation of facial skin) was significantly lower, and IL-1\u03b2 level was significantly higher, in CMM rats on day 7 after CMM. The mean percentage of FG-labeled P2X\n                    <jats:sub>3<\/jats:sub>\n                    R-positive neurons was significantly increased in TG following successive IL-1\u03b2 injections into the MM for 7 days. Successive administration of an IL-1\u03b2 receptor-antagonist into the MM attenuated the increase of P2X\n                    <jats:sub>3<\/jats:sub>\n                    -IR cells in the TG. ATP release from MM after 300-g pressure stimulation of MM was also significantly enhanced after CMM. Administration into MM of the selective P2X\n                    <jats:sub>3<\/jats:sub>\n                    ,\n                    <jats:sub>2\/3<\/jats:sub>\n                    receptor antagonist A-317491 attenuated the decrement of HWT in CMM rats. A significant increase in HWT was also observed at 30 min after A-317491 (60 \u00b5g) injection in IL-1\u03b2-injected rats. These findings suggest that P2X\n                    <jats:sub>3<\/jats:sub>\n                    R expression associated with enhanced IL-1\u03b2 expression and ATP release in MM has a possible important role in MM mechanical hyperalgesia after excessive muscular contraction.\n                  <\/jats:p>","DOI":"10.1177\/0022034513483770","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T22:08:52Z","timestamp":1363903732000},"page":"456-460","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Interaction of IL-1\u03b2 and P2X\n                    <sub>3<\/sub>\n                    Receptor in Pathologic Masseter Muscle Pain"],"prefix":"10.1177","volume":"92","author":[{"given":"N.","family":"Noma","sequence":"first","affiliation":[{"name":"Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, and Division of Clinical Research, Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Shinoda","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nihon University School of Dentistry, 1-8-13 Kandasurugadai, Chiyoda-ku Tokyo, 101-8310, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nihon University School of Dentistry, 1-8-13 Kandasurugadai, Chiyoda-ku Tokyo, 101-8310, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kiyomoto","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, and Division of Clinical Research, Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Dezawa","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, and Division of Clinical Research, Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Nakaya","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, and Division of Clinical Research, Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Komiyama","sequence":"additional","affiliation":[{"name":"Orofacial and Head Pain Clinic, Nihon University School of Dentistry at Matsudo, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, and Division of Clinical Research, Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nihon University School of Dentistry, 1-8-13 Kandasurugadai, Chiyoda-ku Tokyo, 101-8310, 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