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However, the osteoblastic insulin resistance induced by HFD has not been elucidated. Therefore, we hypothesized that 12-week HFD rats exhibited not only peripheral insulin resistance but also osteoblastic insulin resistance, which leads to decreased jawbone quality. We found that the jawbones of rats fed a 12-week HFD exhibited increased osteoporosis. The osteoblastic cells isolated from HFD-fed rats exhibited the impairment of osteoblastic insulin signaling as well as reduction of cell proliferation and survival. In conclusion, this study demonstrated that insulin resistance induced by 12-week HFD impaired osteoblastic insulin signaling, osteoblast proliferation, and osteoblast survival and resulted in osteoporosis in the jawbone.<\/jats:p>","DOI":"10.1177\/0022034513485600","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T22:20:09Z","timestamp":1365459609000},"page":"560-565","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":41,"title":["Decreased Jaw Bone Density and Osteoblastic Insulin Signaling in a Model of Obesity"],"prefix":"10.1177","volume":"92","author":[{"given":"S.N.","family":"Pramojanee","sequence":"first","affiliation":[{"name":"Department of Oral Biology and Diagnostic Science, Faculty of Dentistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Phimphilai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of 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