{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:15:34Z","timestamp":1791000934026,"version":"4.1.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>We have reported a lipopolysaccharide (LPS)-induced hyper-inflammatory response in localized aggressive periodontitis (LAP). It is unknown whether treatment is able to modulate this LPS responsiveness. Fifty-nine individuals with LAP were treated by mechanical debridement and systemic antibiotics. Clinical parameters and cyto\/chemokine responsiveness of whole blood stimulated with Porphyromonas gingivalis or Escherichia coli LPS were monitored at baseline and 3, 6, and 12 months post-treatment. Overall, clinical parameters were improved following treatment. Additionally, P. gingivalis LPS induction of eotaxin, IFN\u03b3, IL10, IL12p40, IL1\u03b2, IL6, IP10, MCP1, MIP1\u03b1, GM-CSF, and TNF\u03b1 was significantly decreased ( p &lt; .05). Similarly, induction of eotaxin, INF\u03b3, IL10, IL12p40, GM-CSF, and TNF\u03b1 by E. coli LPS was also reduced post-treatment. These reductions correlated with decreases in clinical parameters. Importantly, these reductions in LPS responsiveness were most robust at 3 months, and some lost significance at 6 to 12 months post-treatment. In conclusion, LPS-induced hyper-inflammatory response in LAP can be partially modulated by periodontal therapy. Conversely, rebound in the hyper-responsiveness of some mediators, in the presence of improved clinical parameters, suggests that this phenotype could be partially influenced by a genetic trait and play a role in future disease recurrence (ClinicalTrials.gov, NCT01330719).<\/jats:p>","DOI":"10.1177\/0022034513495242","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T23:28:01Z","timestamp":1371770881000},"page":"702-708","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":67,"title":["LPS-induced Inflammatory Response after Therapy of Aggressive Periodontitis"],"prefix":"10.1177","volume":"92","author":[{"given":"L.M.","family":"Shaddox","sequence":"first","affiliation":[{"name":"Department of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA"},{"name":"Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.F.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA"},{"name":"Department of Dentistry, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vovk","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Allin","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Division of Epidemiology, Stony Brook University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Aukhil","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Wallet","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA"},{"name":"Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL, 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