{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:24:20Z","timestamp":1791314660282,"version":"4.3.1"},"reference-count":33,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T00:00:00Z","timestamp":1374537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>Trigeminal neuropathic pain affects millions of people worldwide. Despite decades of study on the neuronal processing of pain, mechanisms underlying enhanced pain states after injury remain unclear. N-methyl-D-aspartate (NMDA) receptor-dependent changes play a critical role in triggering central sensitization in neuropathic pain. These receptors are regulated at the glycine site through a mandatory endogenous co-agonist D-serine, which is synthesized by astrocytes. Therefore, the present study was carried out to determine whether astrocytes are involved, through D-serine secretion, in dynamic mechanical allodynia (DMA) obtained after chronic constriction of the infraorbital nerve (CCI-IoN) in rats. Two weeks after CCI-IoN, an important reaction of astrocytes was present in the medullary dorsal horn (MDH), as revealed by an up-regulation of glial fibrillary acidic protein (GFAP) in allodynic rats. In parallel, an increase in D-serine synthesis, which co-localized with its synthesis enzyme serine racemase, was strictly observed in astrocytes. Blocking astrocyte metabolism by intracisternal delivery of fluorocitrate alleviated DMA. Furthermore, the administration of D-amino-acid oxidase (DAAO), a D-serine-degrading enzyme, or that of L-serine O-sulfate (LSOS), a serine racemase inhibitor, significantly decreased pain behavior in allodynic rats. These results demonstrate that astrocytes are involved in the modulation of orofacial post-traumatic neuropathic pain via the release of the gliotransmitter D-serine.<\/jats:p>","DOI":"10.1177\/0022034513498898","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T13:15:26Z","timestamp":1374671726000},"page":"808-813","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":43,"title":["Astrocytes are Involved in Trigeminal Dynamic Mechanical Allodynia"],"prefix":"10.1177","volume":"92","author":[{"given":"W.","family":"Dieb","sequence":"first","affiliation":[{"name":"7280, Neuro-Psycho-pharmacologie des Syst\u00e8mes Dopaminergiques sous-corticaux, Clermont-Ferrand, Universit\u00e9 Clermont1, F-63000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hafidi","sequence":"additional","affiliation":[{"name":"7280, Neuro-Psycho-pharmacologie des Syst\u00e8mes Dopaminergiques sous-corticaux, Clermont-Ferrand, Universit\u00e9 Clermont1, F-63000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,7,23]]},"reference":[{"key":"bibr1-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.09.003"},{"key":"bibr2-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1021\/jm800200u"},{"key":"bibr3-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2005.04.021"},{"key":"bibr4-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91729-K"},{"key":"bibr5-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0176-07.2007"},{"key":"bibr6-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(03)00110-X"},{"key":"bibr7-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90261-5"},{"key":"bibr8-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(97)00019-1"},{"key":"bibr9-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.01.005"},{"key":"bibr10-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2010.09.012"},{"key":"bibr11-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2552-08.2008"},{"key":"bibr12-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/279147"},{"key":"bibr13-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1038\/nrc747"},{"key":"bibr14-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.02.021"},{"key":"bibr15-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.04.043"},{"key":"bibr16-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03462.x"},{"key":"bibr17-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1259-08.2008"},{"key":"bibr18-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3365-09.2009"},{"key":"bibr19-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.091002298"},{"key":"bibr20-0022034513498898","unstructured":"Paxinos G, Watson C (1997). The rat brain in stereotaxic coordinates. New York, NY: Academic Press, p. 266."},{"key":"bibr21-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.12.023"},{"key":"bibr22-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03514.x"},{"key":"bibr23-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00025.2008"},{"key":"bibr24-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.9.3948"},{"key":"bibr25-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-05-02708.1994"},{"key":"bibr26-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01658-X"},{"key":"bibr27-0022034513498898","doi-asserted-by":"publisher","DOI":"10.2174\/1876386301003010144"},{"key":"bibr28-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1251"},{"key":"bibr29-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1126\/stke.3562006pe41"},{"key":"bibr30-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2006.07.008"},{"key":"bibr31-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2008.06.006"},{"key":"bibr32-0022034513498898","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.12.139"},{"key":"bibr33-0022034513498898","first-page":"817","volume":"22","author":"Zhang YH","year":"2001","journal-title":"Acta Pharmacol Sin"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034513498898","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0022034513498898","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034513498898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:04:18Z","timestamp":1777496658000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0022034513498898"}},"subtitle":["Potential Role of D-serine"],"short-title":[],"issued":{"date-parts":[[2013,7,23]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1177\/0022034513498898"],"URL":"https:\/\/doi.org\/10.1177\/0022034513498898","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,23]]}}}