{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:32:28Z","timestamp":1791322348931,"version":"4.3.1"},"reference-count":26,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T00:00:00Z","timestamp":1374624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>\n                    Autophagy is a catabolic pathway utilized to maintain a balance among the synthesis, degradation, and recycling of cellular components, thereby playing a role in cell growth, development, and homeostasis. Previous studies revealed that a conditional knockout of essential member(s) of autophagy in a variety of tissues causes changes in structure and function of these tissues. Acinar cell-specific expression of knocked-in Cre recombinase through control of aquaporin 5 (Aqp5) promoter\/enhancer ( Aqp5-Cre) allows us to specifically inactivate Atg5, a protein necessary for autophagy, in salivary acinar cells of Atg5\n                    <jats:sup>f\/f<\/jats:sup>\n                    ;Aqp5-Cre mice. There was no difference in apoptotic or proliferation levels in salivary glands of Atg5\/Cre mice from each genotype. However, H&amp;E staining and electron microscopy studies revealed modestly enlarged acinar cells and accumulated secretory granules in salivary glands of Atg5\n                    <jats:sup>f\/f<\/jats:sup>\n                    ;Aqp5-Cre mice. Salivary flow rates and amylase contents of Atg5\/Cre mice indicated that acinar-specific inactivation of ATG5 did not alter carbachol-evoked saliva and amylase secretion. Conversely, autophagy intersected with salivary morphological and secretory manifestations induced by isoproterenol administration. These results identified a role for autophagy as a homeostasis control in salivary glands. Collectively, Atg5\n                    <jats:sup>f\/f<\/jats:sup>\n                    ;Aqp5-Cre mice would be a useful tool to enhance our understanding of autophagy in adaptive responses following targeted head and neck radiation or Sj\u00f6gren syndrome.\n                  <\/jats:p>","DOI":"10.1177\/0022034513499350","type":"journal-article","created":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T11:03:18Z","timestamp":1374750198000},"page":"911-917","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Deletion of ATG5 Shows a Role of Autophagy in Salivary Homeostatic Control"],"prefix":"10.1177","volume":"92","author":[{"given":"M.","family":"Morgan-Bathke","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, The University of Arizona, Tucson, AZ 85721, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.H.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Chibly","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, The University of Arizona, Tucson, AZ 85721, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.-H.","family":"Chen","sequence":"additional","affiliation":[{"name":"Center of Comparative Respiratory Biology and Medicine, University of California at Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Flodby","sequence":"additional","affiliation":[{"name":"Will Rogers Institute, Pulmonary Research Center, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Borok","sequence":"additional","affiliation":[{"name":"Will Rogers Institute, Pulmonary Research Center, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"},{"name":"Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Wu","sequence":"additional","affiliation":[{"name":"Center of Comparative Respiratory Biology and Medicine, University of California at Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Arnett","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, The University of Arizona, Tucson, AZ 85721, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.R.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Arizona, Tucson, AZ 85721, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.K.","family":"Ann","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA"},{"name":"Irell & Mandella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.H.","family":"Limesand","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, The University of Arizona, Tucson, AZ 85721, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,7,24]]},"reference":[{"key":"bibr1-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1177\/10454411970080030101"},{"key":"bibr2-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2010.07.003"},{"key":"bibr3-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.02.009"},{"key":"bibr4-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2012.04.008"},{"key":"bibr5-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.08.016"},{"key":"bibr6-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0226OC"},{"key":"bibr7-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000298"},{"key":"bibr8-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1002\/path.2697"},{"key":"bibr9-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-417"},{"key":"bibr10-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1038\/nature04724"},{"key":"bibr11-0022034513499350","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.7.13038"},{"key":"bibr12-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.08.013"},{"key":"bibr13-0022034513499350","doi-asserted-by":"publisher","DOI":"10.4161\/auto.19496"},{"key":"bibr14-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200412022"},{"key":"bibr15-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.03.035"},{"key":"bibr16-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051363"},{"key":"bibr17-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016778108"},{"key":"bibr18-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2254"},{"key":"bibr19-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-092910-154005"},{"key":"bibr20-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1038\/nm1574"},{"key":"bibr21-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1038\/nature08455"},{"key":"bibr22-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.113092"},{"key":"bibr23-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn292"},{"key":"bibr24-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2009.12"},{"key":"bibr25-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1482"},{"key":"bibr26-0022034513499350","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906048106"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034513499350","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0022034513499350","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034513499350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:03:47Z","timestamp":1777496627000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0022034513499350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,24]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1177\/0022034513499350"],"URL":"https:\/\/doi.org\/10.1177\/0022034513499350","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,24]]}}}