{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:03:43Z","timestamp":1790442223617,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T00:00:00Z","timestamp":1379635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>Osteoporotic conditions are anticipated to affect the osseointegration of dental implants. This study aimed to evaluate the effect of a radiofrequent magnetron-sputtered calcium phosphate (CaP) coating on dental implant integration upon installment in the femoral condyles of both healthy and osteoporotic rats. At 8 weeks post-implantation, bone volume and histomorphometric bone area were lower around non-coated implants in osteoporotic rats compared with healthy rats. Interestingly, push-out tests revealed significantly enhanced implant fixation for CaP-coated compared with non-coated implants in both osteoporotic ( i.e., 2.9-fold) and healthy rats ( i.e., 1.5-fold), with similar implant fixation for CaP-coated implants in osteoporotic conditions compared with that of non-coated implants in healthy conditions. Further, the presence of a CaP coating significantly increased bone-to-implant contact compared with that in non-coated implants in both osteoporotic ( i.e., 1.3-fold) and healthy rats ( i.e., 1.4-fold). Sequential administration of fluorochrome labels showed significantly increased bone dynamics close to CaP-coated implants at 3 weeks of implantation in osteoporotic conditions and significantly decreased bone dynamics in osteoporotic compared with healthy conditions. In conclusion, analysis of the data obtained demonstrated that dental implant modification with a thin CaP coating effectively improves osseointegration in both healthy and osteoporotic conditions.<\/jats:p>","DOI":"10.1177\/0022034513505769","type":"journal-article","created":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T02:27:02Z","timestamp":1379730422000},"page":"982-988","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":50,"title":["Calcium-phosphate-coated Oral Implants Promote Osseointegration in Osteoporosis"],"prefix":"10.1177","volume":"92","author":[{"given":"H.S.","family":"Alghamdi","sequence":"first","affiliation":[{"name":"Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands"},{"name":"Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.M.J.I.","family":"Cuijpers","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.G.C.","family":"Wolke","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.J.P.","family":"van den Beucken","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,9,20]]},"reference":[{"key":"bibr1-0022034513505769","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.02.033"},{"key":"bibr2-0022034513505769","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2012-200854"},{"key":"bibr3-0022034513505769","unstructured":"Bondarenko A, Angrisani N, Meyer-Lindenberg A, Seitz JM, Waizy H, Reifenrath J (2013). Magnesium-based bone implants: immunohistochemical analysis of peri-implant osteogenesis by evaluation of osteopontin and osteocalcin expression. J Biomed Mater Res A [Epub ahead of print 6\/13\/2013] (in press). URL accessed on 8\/28\/2013 at: http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.34828\/abstract."},{"key":"bibr4-0022034513505769","doi-asserted-by":"crossref","unstructured":"Bosco R, Edreira ERU, Wolke JG, Leeuwenburgh SC, van den Beucken JJ, Jansen JA (2013). Instructive coatings for biological guidance of bone implants. Surf Coat Technol [Epub ahead of print 3\/5\/2013] (in press). 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