{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:02:02Z","timestamp":1793145722679,"version":"4.5.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T00:00:00Z","timestamp":1379635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>Here we report the synthesis, materials characterization, antimicrobial capacity, and cytocompatibility of novel antibiotic-containing scaffolds. Metronidazole (MET) or Ciprofloxacin\/(CIP) was mixed with a polydioxanone (PDS)polymer solution at 5 and 25 wt% and processed into fibers. PDS fibers served as a control. Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), tensile testing, and high-performance liquid chromatography (HPLC) were used to assess fiber morphology, chemical structure, mechanical properties, and drug release, respectively. Antimicrobial properties were evaluated against those of Porphyromonas gingivalis\/Pg and Enterococcus faecalis\/Ef. Cytotoxicity was assessed in human dental pulp stem cells (hDPSCs). Statistics were performed, and significance was set at the 5% level. SEM imaging revealed a submicron fiber diameter. FTIR confirmed antibiotic incorporation. The tensile values of hydrated 25 wt% CIP scaffold were significantly lower than those of all other groups. Analysis of HPLC data confirmed gradual, sustained drug release from the scaffolds over 48 hrs. CIP-containing scaffolds significantly ( p &lt; .00001) inhibited biofilm growth of both bacteria. Conversely, MET-containing scaffolds inhibited only Pg growth. Agar diffusion confirmed the antimicrobial properties against specific bacteria for the antibiotic-containing scaffolds. Only the 25 wt% CIP-containing scaffolds were cytotoxic. Collectively, this study suggests that polymer-based antibiotic-containing electrospun scaffolds could function as a biologically safe antimicrobial drug delivery system for regenerative endodontics.<\/jats:p>","DOI":"10.1177\/0022034513505770","type":"journal-article","created":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T02:27:02Z","timestamp":1379730422000},"page":"963-969","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":164,"title":["Bioactive Nanofibrous Scaffolds for Regenerative Endodontics"],"prefix":"10.1177","volume":"92","author":[{"given":"M.C.","family":"Bottino","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry - Division of Dental Biomaterials"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kamocki","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry - Division of Dental Biomaterials"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.H.","family":"Yassen","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry - Division of Dental Biomaterials"},{"name":"Department of Pediatric, Orthodontic, and Preventative Dentistry, Mosul University, School of Dentistry, Mosul, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Platt","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry - Division of Dental Biomaterials"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.M.","family":"Vail","sequence":"additional","affiliation":[{"name":"Department of Endodontics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"Department of Endodontics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.J.","family":"Spolnik","sequence":"additional","affiliation":[{"name":"Department of Endodontics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.L.","family":"Gregory","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Indiana University School of Dentistry (IUSD), Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,9,20]]},"reference":[{"key":"bibr1-0022034513505770","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200404000-00003"},{"key":"bibr2-0022034513505770","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2004.09.003"},{"key":"bibr3-0022034513505770","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.08.019"},{"key":"bibr4-0022034513505770","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2012.04.022"},{"key":"bibr5-0022034513505770","author":"Bottino MC","year":"2013","journal-title":"J Tissue Eng Regen Med"},{"key":"bibr6-0022034513505770","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.11.041"},{"key":"bibr7-0022034513505770","doi-asserted-by":"publisher","DOI":"10.1021\/bm060057z"},{"key":"bibr8-0022034513505770","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511417441"},{"key":"bibr9-0022034513505770","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1996.tb01173.x"},{"key":"bibr10-0022034513505770","unstructured":"International Organization for Standardization (1993). 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