{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:09:30Z","timestamp":1793275770412,"version":"4.5.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T00:00:00Z","timestamp":1381449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>The 2 major forms of periodontitis, chronic (CP) and aggressive (AgP), do not display sufficiently distinct histopathological characteristics or microbiological\/immunological features. We used molecular profiling to explore biological differences between CP and AgP and subsequently carried out supervised classification using machine-learning algorithms including an internal validation. We used whole-genome gene expression profiles from 310 \u2018healthy\u2019 or \u2018diseased\u2019 gingival tissue biopsies from 120 systemically healthy non-smokers, 65 with CP and 55 with AgP, each contributing with \u2265 2 \u2018diseased\u2019 gingival papillae (n = 241; with bleeding-on-probing, probing depth \u2265 4 mm, and clinical attachment loss \u2265 3 mm), and, when available, a \u2018healthy\u2019 papilla (n = 69; no bleeding-on-probing, probing depth \u2264 4 mm, and clinical attachment loss \u2264 4 mm). Our analyses revealed limited differences between the gingival tissue transcriptional profiles of AgP and CP, with genes related to immune responses, apoptosis, and signal transduction overexpressed in AgP, and genes related to epithelial integrity and metabolism overexpressed in CP. Different classifying algorithms discriminated CP from AgP with an area under the curve ranging from 0.63 to 0.99. The small differences in gene expression and the highly variable classifier performance suggest limited dissimilarities between established AgP and CP lesions. Future analyses may facilitate the development of a novel, \u2018intrinsic\u2019 classification of periodontitis based on molecular profiling.<\/jats:p>","DOI":"10.1177\/0022034513506011","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T23:32:42Z","timestamp":1381534362000},"page":"1081-1088","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":75,"title":["Molecular Differences between Chronic and Aggressive Periodontitis"],"prefix":"10.1177","volume":"92","author":[{"given":"M.","family":"Kebschull","sequence":"first","affiliation":[{"name":"Division of Periodontics, Section of Oral and Diagnostic Sciences, Columbia University College of Dental Medicine, New York, NY, USA"},{"name":"Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Guarnieri","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Shared Resources, Bioinformatics Division, Herbert Irving Comprehensive Cancer Center"},{"name":"Columbia Initiative in Systems Biology, Columbia University Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.T.","family":"Demmer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.L.","family":"Boulesteix","sequence":"additional","affiliation":[{"name":"Computational Molecular Medicine Research Group, Department of Medical Informatics, Biometry and Epidemiology, University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Pavlidis","sequence":"additional","affiliation":[{"name":"UBC Centre for High-Throughput Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.N.","family":"Papapanou","sequence":"additional","affiliation":[{"name":"Division of Periodontics, Section of Oral and Diagnostic Sciences, Columbia University College of Dental Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,10,11]]},"reference":[{"key":"bibr1-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"bibr2-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00357.x"},{"key":"bibr3-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00353.x"},{"key":"bibr4-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2007.00223.x"},{"key":"bibr5-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-9-85"},{"key":"bibr6-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002601"},{"key":"bibr7-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080139"},{"key":"bibr8-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk018"},{"key":"bibr9-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-5-10-r80"},{"key":"bibr10-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2012.655725"},{"key":"bibr11-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-820-1_24"},{"key":"bibr12-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01668.x"},{"key":"bibr13-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00895-12"},{"key":"bibr14-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-276-2_12"},{"key":"bibr15-0022034513506011","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201215"},{"key":"bibr16-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-221"},{"key":"bibr17-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2011.178"},{"key":"bibr18-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00327.x"},{"key":"bibr19-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"bibr20-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2006.00869.x"},{"key":"bibr21-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-439"},{"key":"bibr22-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00354.x"},{"key":"bibr23-0022034513506011","doi-asserted-by":"publisher","DOI":"10.2202\/1544-6115.1027"},{"key":"bibr24-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512456551"},{"key":"bibr25-0022034513506011","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"}],"container-title":["Journal 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