{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:22:06Z","timestamp":1789953726841,"version":"4.0.1"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T00:00:00Z","timestamp":1384300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>In this study, we investigated the possibility of using local administration of allogeneic bone marrow mesenchymal stem cells (BMMSCs) to induce tissue regeneration in periodontal defects in a rat model of periodontitis. BMMSCs isolated from rats were mixed with 0.9% NaCl solution and injected into periodontal defects. Control groups were 0.9% NaCl solution or left untreated. The clinical assessments, x-rays, and histological examinations were used to evaluate the effect. At 12 wks post-transplantation, quantitative analysis revealed average probing bone loss values of 1.2 \u00b1 0.19, 1.6 \u00b1 0.2, and 1.7 \u00b1 0.14; the bone regeneration rate was 53%, 45%, and 44% in the BMMSC+NaCl group, NaCl group, and untreated group, respectively. The clinical assessments, x-rays, and histological examinations revealed significant periodontal tissue regeneration in the BMMSC injection group, compared with the control groups. The ELISA results showed that TNF\u03b1, IFN\u03b3, and IL1\u03b2 were 2,674.88 \u00b1 102.77 pg\/mL vs. 3,422.1 \u00b1 51.98 pg\/mL, 609.85 \u00b1 25.5 pg\/mL vs. 803.79 \u00b1 33.85 pg\/mL, and 1,038.46 \u00b1 76.29 pg\/mL vs. 1,175.26 \u00b1 105.55 pg\/mL in the BMMSC+NaCl group and NaCl group, respectively, indicating that BMMSC injection inhibited the inflammatory factors TNF\u03b1, IFN\u03b3, and IL1\u03b2. Our results indicate that local administration of BMMSCs can repair defects due to periodontitis, exerting anti-inflammatory and immunomodulatory functions.<\/jats:p>","DOI":"10.1177\/0022034513513026","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T00:59:48Z","timestamp":1384390788000},"page":"183-188","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":112,"title":["Allogeneic Bone Marrow Mesenchymal Stem Cell Transplantation for Periodontal Regeneration"],"prefix":"10.1177","volume":"93","author":[{"given":"J.","family":"Du","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China"},{"name":"Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Shan","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China"},{"name":"Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ma","sequence":"additional","affiliation":[{"name":"Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wang","sequence":"additional","affiliation":[{"name":"Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China"},{"name":"Department of Biochemistry and Molecular Biology, Capital Medical University School of Basic Medical Sciences, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Fan","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, 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