{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:50:19Z","timestamp":1782003019483,"version":"3.54.5"},"reference-count":37,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T00:00:00Z","timestamp":1411948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>Temporomandibular joint (TMJ) discs frequently undergo degenerative changes in arthritis. However, the biomechanical properties of pathogenic discs remain to be explored. In this study, we evaluated the effects of chronic inflammation on the biomechanical properties of TMJ discs in rats. Chronic inflammation of TMJs was induced by double intra-articular injections of complete Freund\u2019s adjuvant for 5 weeks, and biomechanical properties and ultrastructure of the discs were examined by mechanical testing, scanning electron microscopy, and transmission electron microscopy. The instantaneous compressive moduli of the anterior and posterior bands of discs in inflamed TMJs were decreased significantly compared with those in the control group. The instantaneous tensile moduli of the discs of inflamed TMJs also showed significant decreases in both the anterior-posterior and mesial-lateral directions. The relaxation moduli of the discs of inflamed TMJs showed nearly the same tendency as the instantaneous moduli. The surfaces of the discs of inflamed TMJs became rough and porous due to the loss of the superficial gel-like stratum, with many collagen fibers exposed and degradation of the sub-superficial collagen fibrils. Our results suggested that chronic inflammation of TMJ could lead to deterioration of mechanical properties and alteration of disc ultrastructure, which might contribute to TMJ disc displacement.<\/jats:p>","DOI":"10.1177\/0022034514552825","type":"journal-article","created":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T23:54:12Z","timestamp":1412034852000},"page":"1170-1176","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":46,"title":["Deterioration of Mechanical Properties of Discs in Chronically Inflamed TMJ"],"prefix":"10.1177","volume":"93","author":[{"given":"X.D.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthodontics"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.J.","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Orthodontics"},{"name":"Center for 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