{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:01:21Z","timestamp":1787317281236,"version":"build-2736575974"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T00:00:00Z","timestamp":1415750400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Recent research has verified that mesenchymal stromal\/stem cells (MSCs) derived from bone marrow or adipose tissues can migrate toward a variety of tumors. In this study, we explored whether human gingival-derived MSCs (G-MSCs) can migrate toward tongue squamous cell carcinoma (TSCC) and evaluated the antitumor effect of engineered G-MSCs in expressing and delivering the tumor necrosis factor\u2013related apoptosis-inducing ligand (TRAIL). An in vitro cell migration assay with Transwell plates showed that human G-MSCs can migrate toward TSCC cell lines (Tca8113 and Cal27). Then, human G-MSCs, as a type of cell-based vehicle, were transduced with full-length TRAIL and enhanced green fluorescent protein reporter genes by the lentivirus (LV) system (G-MSCs with full-length TRAIL; G-MSCFLT). Tca8113 and Cal27 were co-cultured with G-MSCFLT, respectively, to evaluate the function of G-MSCFLT on tumor cells in vitro. This resulted in G-MSCFLT\u2019s inducing a great number of tumor cell necrosis and apoptosis. Meanwhile, in vivo antitumor assays were performed by administering G-MSCFLT to nude mice locally and systematically (mixed injection with tumor cells and tail vein injection). This showed that G-MSCFLT can reduce or even inhibit TSCC growth regardless of the method of administration, especially when the mixed injection of tumor cells and G-MSCFLT was at a ratio of 1:1, which showed no tumor formation. Furthermore, this verified that G-MSCFLT migrated toward TSCC in quantity. These data emphasize the effectiveness of G-MSCs as a vehicle for cell-based gene therapy and the antitumor activity of TRAIL-expressing G-MSCs.<\/jats:p>","DOI":"10.1177\/0022034514557815","type":"journal-article","created":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:55:31Z","timestamp":1415840131000},"page":"219-228","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["TRAIL-Expressing Gingival-Derived Mesenchymal Stem Cells Inhibit Tumorigenesis of Tongue Squamous Cell Carcinoma"],"prefix":"10.1177","volume":"94","author":[{"given":"L.","family":"Xia","sequence":"first","affiliation":[{"name":"The Key Laboratory for Oral Biomedical Engineering of Ministry of Education, Hospital and School of Stomatology, Wuhan University, Wuhan, China"},{"name":"Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Peng","sequence":"additional","affiliation":[{"name":"The Key Laboratory for Oral Biomedical Engineering of Ministry of Education, Hospital and School of Stomatology, Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Jia","sequence":"additional","affiliation":[{"name":"The Key Laboratory for Oral Biomedical Engineering of Ministry of Education, Hospital and School of Stomatology, Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Stomatology Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fan","sequence":"additional","affiliation":[{"name":"The Key Laboratory for Oral Biomedical Engineering of Ministry of Education, Hospital and School of Stomatology, Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,11,12]]},"reference":[{"issue":"16","key":"bibr1-0022034514557815","first-page":"4243","volume":"47","author":"Alessandri G","year":"1987","journal-title":"Cancer Res"},{"key":"bibr2-0022034514557815","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6926"},{"key":"bibr3-0022034514557815","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-010-9222-7"},{"key":"bibr4-0022034514557815","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2004-0138"},{"key":"bibr5-0022034514557815","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700104"},{"key":"bibr6-0022034514557815","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09082.x"},{"key":"bibr7-0022034514557815","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006278"},{"key":"bibr8-0022034514557815","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000236098.13804.0b"},{"key":"bibr9-0022034514557815","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.07.015"},{"key":"bibr10-0022034514557815","doi-asserted-by":"crossref","unstructured":"Hu Y, Cheng P, Xue YX, Liu YH. 2012. 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