{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:40:00Z","timestamp":1789404000462,"version":"build-2803163510"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T00:00:00Z","timestamp":1418169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>To date, the precise etiology of molar-incisor hypomineralization (MIH) is uncertain. Vitamin D plays a key role in hard tissue formation. Therefore, this study aimed to analyze the relationship between serum 25-hydroxy-vitamin D (25(OH)D) status and dental health data obtained from 1,048 children in a 10-year follow-up of the Munich GINIplus and LISAplus birth cohorts. The dental examination included the diagnosis of MIH and recording of (non-)cavitated caries lesions in primary and permanent teeth. Serum 25(OH)D concentrations were taken from blood samples of the 10-year investigation and measured with a fully automated, modular system. Different logistic regression and Poisson hurdle models were calculated. MIH was diagnosed in 13.6% of the study population. Approximately 16.4% of the children demonstrated caries-related defects (D3-4MFS &gt; 0). The mean season-adjusted concentration of 25(OH)D was 75.8 nmol\/l (standard deviation 22.0 nmol\/l). After adjusting for sex, age, body mass index, parental education, equivalent income, and television\/personal computer (TV\/PC) viewing hours, a 10 nmol\/l increase in serum 25(OH)D concentrations was significantly associated with a lower odds ratio of having MIH (OR = 0.89; P = 0.006). Furthermore, higher 25(OH)D values were associated with a lower number of caries-affected permanent teeth. It is concluded that elevated serum 25(OH)D concentrations were associated with better dental health parameters.<\/jats:p>","DOI":"10.1177\/0022034514561657","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T23:50:03Z","timestamp":1418255403000},"page":"381-387","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":69,"title":["Elevated Serum 25(OH)-Vitamin D Levels Are Negatively Correlated with Molar-Incisor Hypomineralization"],"prefix":"10.1177","volume":"94","author":[{"given":"J.","family":"K\u00fchnisch","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology, School of Dentistry, Ludwig-Maximilians-University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Thiering","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology I, Helmholtz Zentrum Munich, German 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