{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:34:43Z","timestamp":1788582883623,"version":"build-2803163510"},"reference-count":38,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>Local anesthesia has made dental treatment more comfortable since 1884, but little is known about associated brain mechanisms. Functional magnetic resonance imaging is a modern neuroimaging tool widely used for investigating human brain activity related to sensory perceptions, including pain. Most brain regions that respond to experimental noxious stimuli have recently been found to react not only to nociception alone, but also to visual, auditory, and other stimuli. Thus, presumed functional attributions have come under scrutiny regarding selective pain processing in the brain. Evidently, innovative approaches are warranted to identify cerebral regions that are nociceptive specific. In this study, we aimed at circumventing known methodological confounders by applying a novel paradigm in 14 volunteers: rather than varying the intensity and thus the salience of painful stimuli, we applied repetitive noxious dental stimuli at constant intensity to the left mandibular canine. During the functional magnetic resonance imaging paradigm, we suppressed the nociceptive barrage by a mental nerve block. Brain activity before and after injection of 4% articaine was compared intraindividually on a group level. Dental pain extinction was observed to correspond to activity reduction in a discrete region of the left posterior insular cortex. These results confirm previous reports demonstrating that direct electrical stimulation of this brain region\u2014but not of others\u2014evokes bodily pain sensations. Hence, our investigation adds further evidence to the notion that the posterior insula plays a unique role in nociceptive processing.<\/jats:p>","DOI":"10.1177\/0022034515572022","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:19:52Z","timestamp":1424218792000},"page":"690-696","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["The Human Brain Response to Dental Pain Relief"],"prefix":"10.1177","volume":"94","author":[{"given":"M.L.","family":"Meier","sequence":"first","affiliation":[{"name":"Center of Dental Medicine, University of Zurich, Zurich, Switzerland"},{"name":"Balgrist University Hospital, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Widmayer","sequence":"additional","affiliation":[{"name":"Center of Dental Medicine, University of Zurich, Zurich, Switzerland"},{"name":"Department of Psychiatry (UPK), University of Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Abazi","sequence":"additional","affiliation":[{"name":"Center of Dental Medicine, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Br\u00fcgger","sequence":"additional","affiliation":[{"name":"Center of Dental Medicine, University of Zurich, Zurich, Switzerland"},{"name":"Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Lukic","sequence":"additional","affiliation":[{"name":"Center of Dental Medicine, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"L\u00fcchinger","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.A.","family":"Ettlin","sequence":"additional","affiliation":[{"name":"Center of Dental Medicine, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,2,17]]},"reference":[{"key":"bibr1-0022034515572022","first-page":"7","volume":"22","author":"Baad-Hansen L","year":"2008","journal-title":"J Orofac Pain"},{"key":"bibr2-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1152\/jn.91100.2008"},{"key":"bibr3-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2012.06.002"},{"key":"bibr4-0022034515572022","doi-asserted-by":"publisher","DOI":"10.2344\/0003-3006-59.2.90"},{"key":"bibr5-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012944"},{"key":"bibr6-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(85)90071-5"},{"key":"bibr7-0022034515572022","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2011.00012"},{"key":"bibr8-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511431253"},{"key":"bibr9-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1177\/10454411990100010101"},{"key":"bibr10-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.25.8.745"},{"key":"bibr11-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.05.021"},{"key":"bibr12-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.4.1934"},{"key":"bibr13-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1177\/00220345690480041801"},{"key":"bibr14-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(77)90153-0"},{"key":"bibr15-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90494-4"},{"key":"bibr16-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-18-08183.2002"},{"key":"bibr17-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21416"},{"key":"bibr18-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2012.06.001"},{"key":"bibr19-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512443366"},{"key":"bibr20-0022034515572022","first-page":"609","volume":"40","author":"Hall R","year":"1884","journal-title":"N Y Med J"},{"key":"bibr21-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21131"},{"key":"bibr22-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-010-2340-1"},{"key":"bibr23-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.09.017"},{"key":"bibr24-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-012-0368-4"},{"key":"bibr25-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.2002.06934.x"},{"key":"bibr26-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)28859-5"},{"key":"bibr27-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513512654"},{"key":"bibr28-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.07.014"},{"key":"bibr29-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr265"},{"key":"bibr30-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01863.x"},{"key":"bibr31-0022034515572022","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00526"},{"key":"bibr32-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.09.084"},{"key":"bibr33-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2011.02247.x"},{"key":"bibr34-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21256"},{"key":"bibr35-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1016\/S0987-7053(00)00227-6"},{"key":"bibr36-0022034515572022","first-page":"23","volume-title":"Zahn-Mund-Kiefer-Heilkunde: Zahn\u00e4rztliche Chirurgie","author":"Schwenzer N","year":"2009"},{"key":"bibr37-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.07.012"},{"key":"bibr38-0022034515572022","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(72)90180-X"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034515572022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0022034515572022","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034515572022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:05:35Z","timestamp":1777496735000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0022034515572022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,17]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1177\/0022034515572022"],"URL":"https:\/\/doi.org\/10.1177\/0022034515572022","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,17]]}}}