{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:37:23Z","timestamp":1792179443926,"version":"4.4.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"9_suppl","license":[{"start":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T00:00:00Z","timestamp":1437004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>The aim of this randomized single-blinded active-controlled clinical study was to evaluate the early efficacy of low-dose Escherichia coli\u2013derived recombinant human bone morphogenetic protein 2 (rhBMP-2) soaked with hydroxyapatite granules (BMP-2\/H) as compared with an inorganic bovine bone xenograft (ABX) in maxillary sinus floor augmentation. In a total of 127 subjects who were enrolled at 6 centers, maxillary sinus floors were augmented with 1 mg\/mL of rhBMP-2 (0.5 to 2.0 mg per sinus) and BMP-2\/H (0.5 to 2.0 g; n = 65) or with ABX alone (0.5 to 2.0 g; n = 62). Core biopsies were obtained 3 mo after the augmentation surgery and were analyzed histomorphometrically. The mean new bone formation with BMP-2\/H and ABX augmentation was 16.10% \u00b1 10.52% and 8.25% \u00b1 9.47%, respectively. The BMP-2\/H group was noninferior to the ABX group; the lower limit of the 1-sided 97.5% confidence interval for the difference between the 2 groups was calculated as 4.33%, which was greater than the prespecified noninferiority margin of \u22123.75%. An additional test with the Wilcoxon rank-sum test with a 2-sided 5% significance level showed that bone formation between the 2 groups was significantly different ( P &lt; 0.0001). The soft tissue and residual graft areas showed no significant differences between the groups. With regard to safety, no significant difference between the 2 groups was observed; there was no significant increase in the amount of rhBMP-2 antibody in the serum after BMP-2\/H grafting. Our study suggested that low-dose Escherichia coli\u2013derived rhBMP-2 with hydroxyapatite was effective in early stages for enhanced bone formation after maxillary sinus floor augmentation without harmful adverse events ( Clinicaltrials.gov NCT01634308).<\/jats:p>","DOI":"10.1177\/0022034515594573","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T22:44:47Z","timestamp":1437086687000},"page":"158S-165S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":65,"title":["Efficacy of rhBMP-2\/Hydroxyapatite on Sinus Floor Augmentation"],"prefix":"10.1177","volume":"94","author":[{"given":"H.J.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.H.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.Y.","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.I.","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.B.","family":"Kye","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Samsung Seoul Hospital, School of Medicine, Sungkyunkwan University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.G.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.Y.","family":"Paeng","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.W.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.H.","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam National University, Gwangju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.S.","family":"Kook","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam National University, Gwangju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.J.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Research Institute, BK 21 2nd Program, Seoul National University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.J.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Research Institute, BK 21 2nd Program, Seoul National University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,7,16]]},"reference":[{"key":"bibr1-0022034515594573","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-11-00012"},{"key":"bibr2-0022034515594573","doi-asserted-by":"publisher","DOI":"10.1054\/bjom.2000.0533"},{"key":"bibr3-0022034515594573","first-page":"613","volume":"38","author":"Boyne PJ","year":"1980","journal-title":"J Oral Surg"},{"key":"bibr4-0022034515594573","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.08.018"},{"key":"bibr5-0022034515594573","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.01483"},{"key":"bibr6-0022034515594573","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2011.04.023"},{"key":"bibr7-0022034515594573","doi-asserted-by":"crossref","unstructured":"Carreira AC, Lojudice FH, Halcsik E, Navarro RD, Sogayar MC, Granjeiro JM. 2014. 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