{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:41:35Z","timestamp":1793947295723,"version":"4.8.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>When measured once, psychological stress predicts development of painful temporomandibular disorder (TMD). However, a single measurement fails to characterize the dynamic nature of stress over time. Moreover, effects of stress on pain likely vary according to biological susceptibility. We hypothesized that temporal escalation in stress exacerbates risk for TMD, and the effect is amplified by allelic variants in a gene, catechol- O-methyltransferase (COMT), regulating catechol neurotransmitter catabolism. We used data from the Orofacial Pain: Prospective Evaluation and Risk Assessment prospective cohort study of 2,707 community-dwelling adults with no lifetime history of TMD on enrollment. At baseline and quarterly periods thereafter, the Perceived Stress Scale (PSS) measured psychological stress. Genotyped DNA from blood samples determined COMT diplotypes. During follow-up of 0.25 to 5.2 y, 248 adults developed examiner-verified incident TMD. PSS scores at baseline were 20% greater ( P &lt; 0.001) in adults who developed incident TMD compared with TMD-free controls. Baseline PSS scores increased by 9% ( P = 0.003) during follow-up in cases but remained stable in controls. This stress escalation was limited to incident cases with COMT diplotypes coding for low-activity COMT, signifying impaired catabolism of catecholamines. Cox regression models confirmed significant effects on TMD hazard of both baseline PSS ( P &lt; 0.001), modeled as a time-constant covariate, and change in PSS ( P &lt; 0.001), modeled as a time-varying covariate. Furthermore, a significant ( P = 0.04) interaction of COMT diplotype and time-varying stress showed that a postbaseline increase of 1.0 standard deviation in PSS more than doubled risk of TMD incidence in subjects with low-activity COMT diplotypes (hazard ratio = 2.35; 95% confidence limits: 1.66, 3.32), an effect not found in subjects with high-activity COMT diplotypes (hazard ratio = 1.42; 95% confidence limits: 0.96, 2.09). Findings provide novel insights into dynamic effects of psychological stress on TMD pain, highlighting that effects are most pronounced in individuals whose genetic susceptibility increases responsiveness to catecholamine neurotransmitters.<\/jats:p>","DOI":"10.1177\/0022034515595043","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T22:19:34Z","timestamp":1437517174000},"page":"1187-1195","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":53,"title":["COMT Diplotype Amplifies Effect of Stress on Risk of Temporomandibular Pain"],"prefix":"10.1177","volume":"94","author":[{"given":"G.D.","family":"Slade","sequence":"first","affiliation":[{"name":"Center for Pain Research and Innovation, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"},{"name":"Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"},{"name":"Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.E.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Center for Pain Research and Innovation, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"},{"name":"Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ohrbach","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnostic Sciences, University at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bair","sequence":"additional","affiliation":[{"name":"Center for Pain Research and Innovation, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"},{"name":"Department of Endodontics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"},{"name":"Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Maixner","sequence":"additional","affiliation":[{"name":"Center for Pain Research and Innovation, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"},{"name":"Department of Endodontics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.D.","family":"Greenspan","sequence":"additional","affiliation":[{"name":"Department of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA"},{"name":"Brotman Facial Pain Clinic, University of Maryland School of Dentistry, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.B.","family":"Fillingim","sequence":"additional","affiliation":[{"name":"Department of Community Dentistry & Behavioral Science, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Smith","sequence":"additional","affiliation":[{"name":"Center for Pain Research and Innovation, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"},{"name":"Department of Endodontics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Diatchenko","sequence":"additional","affiliation":[{"name":"Allan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,7,21]]},"reference":[{"key":"bibr1-0022034515595043","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.02.040"},{"key":"bibr2-0022034515595043","unstructured":"Allison PD; SAS Institute. 1995. 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