{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:22:48Z","timestamp":1781677368394,"version":"3.54.5"},"reference-count":41,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T00:00:00Z","timestamp":1457308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>\n                    Certain mutations in the COL1A1 and COL1A2 genes produce clinical symptoms of both osteogenesis imperfecta (OI) and Ehlers-Danlos syndrome (EDS) that include abnormal craniofacial growth, dental malocclusion, and dentinogenesis imperfecta. A mouse model ( Col1a1\n                    <jats:sup>Jrt<\/jats:sup>\n                    \/+) was recently developed that had a skeletal phenotype and other features consistent with moderate-to-severe OI and also with EDS. The craniofacial phenotype of 4- and 20-wk-old Col1a1\n                    <jats:sup>Jrt<\/jats:sup>\n                    \/+ mice and wild-type littermates was assessed by micro\u2013computed tomography (\u00b5CT) and morphometry. Teeth and the periodontal ligament compartment were analyzed by \u00b5CT, light microscopy\/histomorphometry, and electron microscopy. Over time, at 20 wk, Col1a1\n                    <jats:sup>Jrt<\/jats:sup>\n                    \/+ mice developed smaller heads, a shortened anterior cranial base, class III occlusion, and a mandibular side shift with shorter morphology in the masticatory region (maxilla and mandible). Col1a1\n                    <jats:sup>Jrt<\/jats:sup>\n                    \/+ mice also had changes in the periodontal compartment and abnormalities in the dentin matrix and mineralization. These findings validate Col1a1\n                    <jats:sup>Jrt<\/jats:sup>\n                    \/+ mice as a model for OI and EDS in humans.\n                  <\/jats:p>","DOI":"10.1177\/0022034516637045","type":"journal-article","created":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T23:08:55Z","timestamp":1457392135000},"page":"761-768","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Craniofacial and Dental Defects in the\n                    <i>Col1a1<\/i>\n                    <sup>Jrt\/+<\/sup>\n                    Mouse Model of Osteogenesis Imperfecta"],"prefix":"10.1177","volume":"95","author":[{"given":"H.","family":"Eimar","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, McGill University, Montreal, QC, Canada"},{"name":"School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Tamimi","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-M.","family":"Retrouvey","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Rauch","sequence":"additional","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E.","family":"Aubin","sequence":"additional","affiliation":[{"name":"Centre for Modeling Human Disease, Toronto Centre for Phenogenomics, Toronto, ON, Canada"},{"name":"Department of Molecular Genetics, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"McKee","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, McGill University, Montreal, QC, Canada"},{"name":"Department of Anatomy and Cell Biology, Faculty of Medicine, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,3,7]]},"reference":[{"key":"bibr1-0022034516637045","doi-asserted-by":"publisher","DOI":"10.4103\/2278-9588.105697"},{"key":"bibr2-0022034516637045","doi-asserted-by":"publisher","DOI":"10.1067\/mod.2003.7"},{"key":"bibr3-0022034516637045","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414698200"},{"key":"bibr4-0022034516637045","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjl035"},{"key":"bibr5-0022034516637045","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2177"},{"key":"bibr6-0022034516637045","doi-asserted-by":"publisher","DOI":"10.1126\/science.7123221"},{"key":"bibr7-0022034516637045","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.7.1228"},{"key":"bibr8-0022034516637045","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2008.00970.x"},{"key":"bibr9-0022034516637045","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2006.08.007"},{"key":"bibr10-0022034516637045","doi-asserted-by":"publisher","DOI":"10.1111\/ede.12025"},{"key":"bibr11-0022034516637045","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-142X.2006.00139.x"},{"key":"bibr12-0022034516637045","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.487"},{"key":"bibr13-0022034516637045","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2015.01.029"},{"key":"bibr14-0022034516637045","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.250"},{"key":"bibr15-0022034516637045","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2003.61"},{"key":"bibr16-0022034516637045","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22752"},{"issue":"6","key":"bibr17-0022034516637045","first-page":"330","volume":"67","author":"L\u00e9tourneau Y","year":"2001","journal-title":"J Can Dent Assoc"},{"issue":"3","key":"bibr18-0022034516637045","first-page":"235","volume":"8","author":"Lukinmaa PL","year":"1988","journal-title":"J Craniofac Genet Dev Biol"},{"key":"bibr19-0022034516637045","doi-asserted-by":"publisher","DOI":"10.2319\/083012-698.1"},{"key":"bibr20-0022034516637045","unstructured":"Newmann MG, Takei HH, Carranza FA editors. 2003. 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