{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:02:44Z","timestamp":1787018564983,"version":"build-2736575974"},"reference-count":36,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T00:00:00Z","timestamp":1458777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>The aim of this study was to assess the changes occurring in subgingival biofilm composition and in the periodontal clinical parameters of subjects with periodontitis and type 2 diabetes mellitus (DM) treated by means of scaling and root planing (SRP) only or combined with systemic metronidazole (MTZ) and amoxicillin (AMX). Fifty-eight subjects were randomly assigned to receive SRP only ( n = 29) or with MTZ (400 mg\/thrice a day [TID]) and AMX (500 mg\/TID) ( n = 29) for 14 d. Six subgingival plaque samples\/subject were analyzed by checkerboard DNA\u2013DNA hybridization for 40 bacterial species at baseline and 3 mo, 1 y, and 2 y posttherapy. At 2 y posttherapy, the antibiotic-treated group harbored lower mean proportions (5.5%) of red complex pathogens than the control group (12.1%) ( P &lt; 0.05). The proportions of the Actinomyces species remained stable in the antibiotic group but showed a statistically significant reduction in the control group from 1 to 2 y in subjects achieving a low risk clinical profile for future disease progression (i.e., \u22644 sites with probing depth [PD] \u22655 mm). The test group also had a lower mean number of sites with PD \u22655 mm (3.5 \u00b1 3.4) and a higher percentage of subjects reaching the low risk clinical profile (76%) than the control group (14.7 \u00b1 13.1 and 22%, respectively) ( P &lt; 0.05) at 2 y posttreatment. MTZ + AMX intake was the only significant predictor of subjects achieving the low risk at 2 y (odds ratio, 20.9; P = 0.0000). In conclusion, the results of this study showed that the adjunctive use of MTZ + AMX improves the microbiological and clinical outcomes of SRP in the treatment of subjects with generalized chronic periodontitis and type 2 DM up to 2 y ( ClinicalTrials.gov NCT02135952).<\/jats:p>","DOI":"10.1177\/0022034516639274","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T20:46:42Z","timestamp":1458852402000},"page":"829-836","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":54,"title":["Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes"],"prefix":"10.1177","volume":"95","author":[{"given":"N.S.","family":"Tamashiro","sequence":"first","affiliation":[{"name":"Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, S\u00e3o Paulo, 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