{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T07:12:14Z","timestamp":1788592334096,"version":"build-2803163510"},"reference-count":37,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>\n                    Chronic periodontitis (CP) has a genetic component, particularly its severe forms. Evidence from genome-wide association studies (GWASs) has highlighted several potential novel loci. Here, the authors report the first GWAS of CP among a large community-based sample of Hispanics\/Latinos. The authors interrogated a quantitative trait of CP (mean interproximal clinical attachment level determined by full-mouth periodontal examinations) among 10,935 adult participants (mean age: 45 y, range: 18 to 76 y) from the Hispanic Community Health Study \/ Study of Latinos. Genotyping was done with a custom Illumina Omni2.5M array, and imputation to approximately 20 million single-nucleotide polymorphisms was based on the 1000 Genomes Project phase 1 reference panel. Analyses were based on linear mixed models adjusting for sex, age, study design features, ancestry, and kinship and employed a conventional\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 5 \u00d7 10\n                    <jats:sup>\u22128<\/jats:sup>\n                    statistical significance threshold. The authors identified a genome-wide significant association signal in the 1q42.2 locus (\n                    <jats:italic toggle=\"yes\">TSNAX-DISC1<\/jats:italic>\n                    noncoding RNA, lead single-nucleotide polymorphism: rs149133391, minor allele [C] frequency = 0.01,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 7.9 \u00d7 10\n                    <jats:sup>\u22129<\/jats:sup>\n                    ) and 4 more loci with suggestive evidence of association (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 5 \u00d7 10\n                    <jats:sup>\u22126<\/jats:sup>\n                    ): 1q22 (rs13373934), 5p15.33 (rs186066047), 6p22.3 (rs10456847), and 11p15.1 (rs75715012). We tested these loci for replication in independent samples of European-American (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 4,402) and African-American (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 908) participants of the Atherosclerosis Risk in Communities study. There was no replication among the European Americans; however, the\n                    <jats:italic toggle=\"yes\">TSNAX-DISC1<\/jats:italic>\n                    locus replicated in the African-American sample (rs149133391, minor allele frequency = 0.02,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 9.1 \u00d7 10\n                    <jats:sup>\u22123<\/jats:sup>\n                    ), while the 1q22 locus was directionally concordant and nominally significant (rs13373934,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 4.0 \u00d7 10\n                    <jats:sup>\u22122<\/jats:sup>\n                    ). This discovery GWAS of interproximal clinical attachment level\u2014a measure of lifetime periodontal tissue destruction\u2014was conducted in a large, community-based sample of Hispanic\/Latinos. It identified a genome-wide significant locus that was independently replicated in an African-American population. Identifying this genetic marker offers direction for interrogation in subsequent genomic and experimental studies of CP.\n                  <\/jats:p>","DOI":"10.1177\/0022034516664509","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T23:02:32Z","timestamp":1473202952000},"page":"64-72","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":61,"title":["Chronic Periodontitis Genome-wide Association Study in the Hispanic Community Health Study \/ Study of Latinos"],"prefix":"10.1177","volume":"96","author":[{"given":"A.E.","family":"Sanders","sequence":"first","affiliation":[{"name":"Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sofer","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.F.","family":"Kerr","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Agler","sequence":"additional","affiliation":[{"name":"Oral and Craniofacial Health Sciences, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.R.","family":"Shaffer","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.D.","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Offenbacher","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Center for Oral and Systemic Diseases, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.R.","family":"Salazar","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Department of Population Health, Albert Einstein College of Medicine and Montefiore Medical Center, New York City, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.E.","family":"North","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.L.","family":"Marazita","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Clinical and Translational Science Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.C.","family":"Laurie","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.H.","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.L.","family":"Finlayson","sequence":"additional","affiliation":[{"name":"Graduate School of Public Health, San Diego State University, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Divaris","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"},{"name":"Department of Pediatric Dentistry, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 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