{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:01:26Z","timestamp":1791489686621,"version":"4.3.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,11,13]],"date-time":"2016-11-13T00:00:00Z","timestamp":1478995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>X-linked hypophosphatemia (XLH) is a rare genetic skeletal disease where increased phosphate wasting in the kidney leads to hypophosphatemia and prevents normal mineralization of bone and dentin. Here, we examined the periodontal status of 34 adults with XLH and separated them according to the treatment they received for hypophosphatemia. We observed that periodontitis frequency and severity were increased in adults with XLH and that the severity varied according to the hypophosphatemia treatment. Patients who benefited from an early and continuous vitamin D and phosphate supplementation during their childhood presented less periodontal attachment loss than patients with late or incomplete supplementation. Continued hypophosphatemia treatment during adulthood further improved the periodontal health. Extracted teeth from patients with late or incomplete supplementation showed a strong acellular cementum hypoplasia when compared with age-matched healthy controls. These results show that XLH disturbs not only bone and dentin formation but also cementum and that the constitutional defect of the attachment apparatus is associated with attachment loss.<\/jats:p>","DOI":"10.1177\/0022034516677528","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T20:36:16Z","timestamp":1478550976000},"page":"388-395","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":110,"title":["Phosphate and Vitamin D Prevent Periodontitis in X-Linked Hypophosphatemia"],"prefix":"10.1177","volume":"96","author":[{"given":"M.","family":"Biosse Duplan","sequence":"first","affiliation":[{"name":"Service d\u2019Odontologie, H\u00f4pital Bretonneau, HUPNVS, AP-HP, Paris, France"},{"name":"Facult\u00e9 de Chirurgie Dentaire, Universit\u00e9 Paris Descartes, Montrouge, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares du M\u00e9tabolisme du Calcium et du Phosphore, Plateforme d\u2019expertise Paris Sud Maladies rares, fili\u00e8re OSCAR, H\u00f4pital Bic\u00eatre-Paris Sud, AP-HP, Le Kremlin Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.R.","family":"Coyac","sequence":"additional","affiliation":[{"name":"EA 2496, Facult\u00e9 de Chirurgie Dentaire, Universit\u00e9 Paris Descartes, Montrouge, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bardet","sequence":"additional","affiliation":[{"name":"EA 2496, Facult\u00e9 de Chirurgie Dentaire, Universit\u00e9 Paris Descartes, Montrouge, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Zadikian","sequence":"additional","affiliation":[{"name":"Service d\u2019Odontologie, H\u00f4pital Bretonneau, HUPNVS, AP-HP, Paris, France"},{"name":"Facult\u00e9 de Chirurgie Dentaire, Universit\u00e9 Paris Descartes, Montrouge, 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