{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:03:35Z","timestamp":1780473815477,"version":"3.54.1"},"reference-count":42,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T00:00:00Z","timestamp":1483660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"crossref","award":["201506010245"],"award-info":[{"award-number":["201506010245"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"crossref"}]},{"name":"International Science & Technology Cooperation Program of China","award":["2015DFB30040"],"award-info":[{"award-number":["2015DFB30040"]}]},{"name":"Beijing Municipal Natural Science Foundation","award":["7152156"],"award-info":[{"award-number":["7152156"]}]},{"name":"National Science Foundations of China","award":["81300850"],"award-info":[{"award-number":["81300850"]}]},{"name":"National Science Foundations of China","award":["81300897"],"award-info":[{"award-number":["81300897"]}]},{"name":"National Science Foundations of China","award":["81470717"],"award-info":[{"award-number":["81470717"]}]},{"name":"National Science Foundations of China","award":["81571815"],"award-info":[{"award-number":["81571815"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>\n                    Immunologic response plays an important role in orthodontic tooth movement (OTM) and relapse. Nonsteroidal anti-inflammatory drugs, such as aspirin, affect immune cells and clinical orthodontic treatment. However, the mechanisms by which nonsteroidal anti-inflammatory drugs regulate immune cells to affect orthodontic relapse are unclear. In this study, male Sprague-Dawley rats were grouped as relapse and relapse + aspirin for 10 d after 14 d of OTM. Silicone impressions of the rats\u2019 maxillary dentitions were obtained to record the distance of OTM at the indicated time point. CD4\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes in spleen were examined by flow cytometry. Serum levels of type 1 T-helper (Th1) cell\u2013associated cytokines tumor necrosis factor \u03b1 (TNF-\u03b1), and interferon \u03b3 (IFN-\u03b3) were determined through enzyme-linked immunosorbent assay. The effects of aspirin on CD4\n                    <jats:sup>+<\/jats:sup>\n                    T and Th1 cells were also analyzed in vitro. Aspirin treatment significantly reduced the relapse rate. More interestingly, injection of CD25 neutralizing antibody basiliximab or TNF-\u03b1 inhibitor etanercept can significantly reduce the relapse rate as well. Correspondingly, aspirin treatment significantly accelerated the decrease of orthodontic force\u2013induced secretion of TNF-\u03b1 and IFN-\u03b3 in serum and the expression of TNF-\u03b1 and IFN-\u03b3 in periodontal ligament during relapse. Furthermore, aspirin treatment in vitro significantly repressed the differentiation of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T and Th1 cells. Overall, results indicated that aspirin treatment can block orthodontic relapse by regulating Th1 cells.\n                  <\/jats:p>","DOI":"10.1177\/0022034516685527","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T11:19:10Z","timestamp":1483787950000},"page":"586-594","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["Aspirin Blocks Orthodontic Relapse via Inhibition of CD4\n                    <sup>+<\/sup>\n                    T Lymphocytes"],"prefix":"10.1177","volume":"96","author":[{"given":"Y.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration, Peking University School and Hospital of Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration, Peking University School and Hospital of Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration, Peking University School and Hospital of Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.S.","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration, Peking University School and Hospital of Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.L.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration, Peking University School and Hospital of Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.D.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration, Peking University School and Hospital of Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Jiang","sequence":"additional","affiliation":[{"name":"Center Laboratory, School and Hospital of Stomatology, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.H.","family":"Gan","sequence":"additional","affiliation":[{"name":"Center Laboratory, School and Hospital of Stomatology, Peking University, Beijing, China"},{"name":"Center for Temporomandibular Disorders and Orofacial Pain, Peking University School and Hospital of Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.X.","family":"Kou","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration, Peking University School and Hospital of Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.H.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration, Peking University School and Hospital of Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,1,6]]},"reference":[{"issue":"9","key":"bibr1-0022034516685527","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.4049\/jimmunol.148.9.2845","volume":"148","author":"Anastassiou ED","year":"1992","journal-title":"J 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