{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T10:42:50Z","timestamp":1793270570008,"version":"4.5.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the National Science Foundations of China","award":["No. 81300850 (X.W.)"],"award-info":[{"award-number":["No. 81300850 (X.W.)"]}]},{"name":"the National Science Foundations of China","award":["No. 81300897 (X.K.)"],"award-info":[{"award-number":["No. 81300897 (X.K.)"]}]},{"name":"the National Science Foundations of China","award":["No. 81470717 (Y.Z.)"],"award-info":[{"award-number":["No. 81470717 (Y.Z.)"]}]},{"name":"the National Science Foundations of China","award":["No. 81571815 (Y.L.)"],"award-info":[{"award-number":["No. 81571815 (Y.L.)"]}]},{"name":"the Beijing Municipal Natural Science Foundation","award":["No. 7152156 (Y.L.)"],"award-info":[{"award-number":["No. 7152156 (Y.L.)"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>\n                    Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S), a gasotransmitter, has been recently linked to mesenchymal stem cell (MSC) function and bone homeostasis. Periodontal ligament stem cells (PDLSCs) are the main MSCs in PDL, which respond to mechanical force to induce physiological activities during orthodontic tooth movement (OTM). However, it is unknown whether mechanical force might induce endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S production by PDLSCs to regulate alveolar bone homeostasis. Here, we used a mouse OTM model to demonstrate that orthodontic force-induced endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S production in PDL tissue was associated with macrophage accumulation and osteoclastic activity in alveolar bone. Then, we showed that mechanical force application induced cystathionine \u03b2-synthase (CBS) expression and endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S production by PDLSCs. Moreover, blocking endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S or systemically increasing H\n                    <jats:sub>2<\/jats:sub>\n                    S levels could decrease or enhance force-induced osteoclastic activities to control tooth movement. We further revealed how force-induced H\n                    <jats:sub>2<\/jats:sub>\n                    S production by PDLSCs contributed to the secretion of monocyte chemoattractant protein-1 (MCP-1) and the expression of receptor activator of nuclear factor\u2013\u03baB ligand\/osteoprotegerin (RANKL\/OPG) system by PDLSCs. The secretion and expression of these factors controlled macrophage migration and osteoclast differentiation. This study demonstrated that PDLSCs produced H\n                    <jats:sub>2<\/jats:sub>\n                    S to respond to and transduce force signals. Force-induced gasotransmitter H\n                    <jats:sub>2<\/jats:sub>\n                    S production in PDLSCs therefore regulated osteoclastic activities in alveolar bone and controlled the OTM process through the MCP-1 secretion and RANKL\/OPG system.\n                  <\/jats:p>","DOI":"10.1177\/0022034517690388","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T08:07:43Z","timestamp":1486454863000},"page":"694-702","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":70,"title":["Force-Induced H\n                    <sub>2<\/sub>\n                    S by PDLSCs Modifies Osteoclastic Activity during Tooth Movement"],"prefix":"10.1177","volume":"96","author":[{"given":"F.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"He","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Kou","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. China"},{"name":"Center for Craniofacial Stem Cell Research and Regeneration, Peking University School and Hospital of Stomatology, Haidian District, Beijing, P.R. 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