{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:47:38Z","timestamp":1777812458520,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T00:00:00Z","timestamp":1494547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>\n                    Under hypotonic conditions, the regulatory volume decrease (RVD) is essential to maintain physiological homeostasis and functions in diverse biological systems. Intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    has been reported as an important mediator of this response, but the underlying Ca\n                    <jats:sup>2+<\/jats:sup>\n                    mechanism responsible for RVD is still controversial. Here we investigate the role of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    in the RVD response using live-cell imaging, microspectrofluorimetry, and a patch-clamp technique. A typical RVD was observed in submandibular gland acinar cells after swelling in a hypotonic solution, whereas intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    chelation completely inhibited the RVD response. The incidence and magnitude of the Ca\n                    <jats:sup>2+<\/jats:sup>\n                    transient were proportional to the degree of hypotonicity of the extracellular medium, and there was a close relationship between intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    concentration and the volumetric changes of the cells. Notably, this response was mediated by Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -induced Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release, which is triggered by Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx via stretch-activated TRPM7 channels. Furthermore, we detected the generation of Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    currents in the swelling acinar cells upon hypotonic stress, and the current profile matched that of the Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -activated Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    currents. A specific inhibitor of Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    currents also inhibited the RVD response. In conclusion, an intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    increase in response to osmotically induced cell swelling plays a critical role in RVD in salivary gland acinar cells.\n                  <\/jats:p>","DOI":"10.1177\/0022034517708766","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T19:51:44Z","timestamp":1494618704000},"page":"1044-1050","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["TRPM7 Is Involved in Volume Regulation in Salivary Glands"],"prefix":"10.1177","volume":"96","author":[{"given":"J.M.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Dentistry, Seoul National University, & Dental Research Institute, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Dentistry, Seoul National University, & Dental Research Institute, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Dentistry, Seoul National University, & Dental Research Institute, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,5,12]]},"reference":[{"key":"bibr1-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409708200"},{"key":"bibr2-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.021980"},{"key":"bibr3-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020695"},{"key":"bibr4-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021149"},{"key":"bibr5-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1177\/153537020022500105"},{"key":"bibr6-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1038\/nature12354"},{"key":"bibr7-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-005-1456-9"},{"key":"bibr8-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2011.12.001"},{"key":"bibr9-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1126\/science.2500708"},{"key":"bibr10-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.95.1.97"},{"key":"bibr11-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1007\/BF00656997"},{"key":"bibr12-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00037.2007"},{"key":"bibr13-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1007\/s002329900236"},{"key":"bibr14-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1007\/BF00233476"},{"key":"bibr15-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600549200"},{"key":"bibr16-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1177\/153537020022500308"},{"key":"bibr17-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00409.x"},{"key":"bibr18-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01858.x"},{"key":"bibr19-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1007\/BF01998085"},{"key":"bibr20-0022034517708766","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.67.041703.084745"},{"issue":"3","key":"bibr21-0022034517708766","first-page":"F402","volume":"260","author":"Montrose-Rafizadeh 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