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Hypertrophic scar (HTS) formation is a frequent postoperative complication that impairs soft tissue form, function, or movement. Multiple lip revision operations are often required throughout childhood, attempting to optimize aesthetics and function. The mechanisms guiding HTS formation are multifactorial and complex. HTS is the result of dysregulated wound healing, where excessive collagen and extracellular matrix proteins are deposited within the wound area, resulting in persistent inflammation and resultant fibrosis. Many studies support the contribution of dysregulated, exaggerated inflammation in scar formation. Fibrosis and scarring result from chronic inflammation that interrupts tissue remodeling in normal wound healing. Failure of active resolution of inflammation pathways has been implicated. The management of HTS has been challenging for clinicians, since current therapies are minimally effective. Emerging evidence that specialized proresolving mediators of inflammation accelerate wound healing by preventing chronic inflammation and allowing natural uninterrupted tissue remodeling suggests new therapeutic opportunities in the prevention and management of HTS.<\/jats:p>","DOI":"10.1177\/0022034517717261","type":"journal-article","created":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T14:03:34Z","timestamp":1498485814000},"page":"1370-1377","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Current and Emerging Treatments for Postsurgical Cleft Lip Scarring: Effectiveness and Mechanisms"],"prefix":"10.1177","volume":"96","author":[{"given":"E.","family":"Papathanasiou","sequence":"first","affiliation":[{"name":"Center for Clinical and Translational Research, Forsyth Institute, Cambridge, MA, USA"},{"name":"Department of Periodontology, Tufts University School of Dental Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.A.","family":"Trotman","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Tufts University School of Dental Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.R.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Pediatrics, Tufts University School of Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.E.","family":"Van Dyke","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Research, Forsyth Institute, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,6,26]]},"reference":[{"key":"bibr1-0022034517717261","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000187147.73963.a5"},{"key":"bibr2-0022034517717261","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2015.4"},{"key":"bibr3-0022034517717261","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2012.00853.x"},{"key":"bibr4-0022034517717261","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2015.11.015"},{"key":"bibr5-0022034517717261","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.05.006"},{"key":"bibr6-0022034517717261","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1995.1227"},{"key":"bibr7-0022034517717261","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000416"},{"key":"bibr8-0022034517717261","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3911"},{"key":"bibr9-0022034517717261","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328330da9b"},{"key":"bibr10-0022034517717261","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2933"},{"key":"bibr11-0022034517717261","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0802406"},{"key":"bibr12-0022034517717261","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009337"},{"key":"bibr13-0022034517717261","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-33065"},{"key":"bibr14-0022034517717261","doi-asserted-by":"crossref","unstructured":"Ferguson MW, O\u2019Kane S. 2004. 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