{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:21:19Z","timestamp":1793254879944,"version":"4.5.0"},"reference-count":61,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>In past decades, morphologic, molecular, and cellular mechanisms that govern tooth development have been extensively studied. These studies demonstrated that the same signaling pathways regulate development of the primary and successional teeth. Mutations of these pathways lead to abnormalities in tooth development and number, including aberrant tooth shape, tooth agenesis, and formation of extra teeth. Here, we summarize the current knowledge on the development of the primary and successional teeth in animal models and describe some of the common tooth abnormalities in humans.<\/jats:p>","DOI":"10.1177\/0022034517720158","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T15:49:02Z","timestamp":1502120942000},"page":"1248-1256","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":80,"title":["The Biology Underlying Abnormalities of Tooth Number in Humans"],"prefix":"10.1177","volume":"96","author":[{"given":"E.","family":"Juuri","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Balic","sequence":"additional","affiliation":[{"name":"Research Program in Developmental Biology, Institute of Biotechnology, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"key":"bibr1-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1086\/520064"},{"key":"bibr2-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1242\/dev.054668"},{"key":"bibr3-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201512074"},{"key":"bibr4-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073705"},{"key":"bibr5-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36243"},{"key":"bibr6-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctdb.2015.07.006"},{"key":"bibr7-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-016-0349-4"},{"key":"bibr8-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.11.002"},{"key":"bibr9-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12160"},{"key":"bibr10-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1698954"},{"key":"bibr11-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515581644"},{"key":"bibr12-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21384"},{"key":"bibr13-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074484"},{"key":"bibr14-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1242\/dev.052415"},{"key":"bibr15-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.09.003"},{"key":"bibr16-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500210"},{"key":"bibr17-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2007.00464.x"},{"key":"bibr18-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1002\/jez.b.21091"},{"key":"bibr19-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607289103"},{"key":"bibr20-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1002\/jez.b.21275"},{"key":"bibr21-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-142X.2008.00258.x"},{"key":"bibr22-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1990.tb00803.x"},{"key":"bibr23-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1242\/dev.085084"},{"key":"bibr24-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1086\/321271"},{"key":"bibr25-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2013.11.004"},{"key":"bibr26-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1242\/dev.089599"},{"key":"bibr27-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515608168"},{"key":"bibr28-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1086\/386293"},{"key":"bibr29-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02325"},{"key":"bibr30-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.10.016"},{"key":"bibr31-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1612354113"},{"key":"bibr32-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.08.014"},{"key":"bibr33-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(03)00020-0"},{"key":"bibr34-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36520"},{"key":"bibr35-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1242\/dev.025064"},{"key":"bibr36-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00157-X"},{"key":"bibr37-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307502200"},{"key":"bibr38-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1002\/jez.b.21277"},{"key":"bibr39-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.05.024"},{"key":"bibr40-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.03.007"},{"key":"bibr41-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33556"},{"key":"bibr42-0022034517720158","unstructured":"Oo\u00eb T. 1981. Human tooth and dental arch development. Tokyo (Japan): Ishiyaku Publishers Inc."},{"key":"bibr43-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12130"},{"key":"bibr44-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9514"},{"key":"bibr45-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12522"},{"key":"bibr46-0022034517720158","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00029"},{"key":"bibr47-0022034517720158","doi-asserted-by":"publisher","DOI":"10.4103\/0976-9668.136222"},{"key":"bibr48-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20721"},{"key":"bibr49-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.23.4.291"},{"key":"bibr50-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1038\/ng1296-392"},{"key":"bibr51-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2010.00772.x"},{"key":"bibr52-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1038\/71634"},{"key":"bibr53-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2007.12.006"},{"key":"bibr54-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1038\/ng0896-417"},{"key":"bibr55-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400206"},{"key":"bibr56-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20715"},{"key":"bibr57-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1242\/dev.033803"},{"key":"bibr58-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.111"},{"key":"bibr59-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515583999"},{"key":"bibr60-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1126\/science.1167418"},{"key":"bibr61-0022034517720158","doi-asserted-by":"publisher","DOI":"10.1086\/316914"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034517720158","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0022034517720158","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034517720158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:07:18Z","timestamp":1777496838000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0022034517720158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,7]]},"references-count":61,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1177\/0022034517720158"],"URL":"https:\/\/doi.org\/10.1177\/0022034517720158","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,7]]}}}