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We also tested the association of previously identified risk variants, for timing of tooth eruption and orofacial clefts, with TA. We report associations between TA and 9 novel risk variants. Five of these variants associate with selective TA, including a variant conferring risk of orofacial clefts. These results contribute to a deeper understanding of the genetic architecture of tooth development and disease. The few variants previously associated with TA were uncovered through candidate gene studies guided by mouse knockouts. Knowing the etiology and clinical features of TA is important for planning oral rehabilitation that often involves an interdisciplinary approach.<\/jats:p>","DOI":"10.1177\/0022034517750109","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T15:40:32Z","timestamp":1516808432000},"page":"515-522","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["Rare and Common Variants Conferring Risk of Tooth Agenesis"],"prefix":"10.1177","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3175-103X","authenticated-orcid":false,"given":"L.","family":"Jonsson","sequence":"first","affiliation":[{"name":"deCODE genetics\/Amgen, Reykjavik, Iceland"},{"name":"Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 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