{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:51:34Z","timestamp":1777812694935,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Shenzhen Science and Technology Funding","award":["JCYJ20160429185449249"],"award-info":[{"award-number":["JCYJ20160429185449249"]}]},{"name":"Shenzhen Science and Technology Funding","award":["JCYJ20160429190821781"],"award-info":[{"award-number":["JCYJ20160429190821781"]}]},{"name":"Hong Kong Research Grant Council General Research Fund","award":["17114814"],"award-info":[{"award-number":["17114814"]}]},{"name":"Hong Kong Research Grant Council General Research Fund","award":["17120718"],"award-info":[{"award-number":["17120718"]}]},{"name":"Hong Kong Research Grant Council General Research Fund","award":["17121616"],"award-info":[{"award-number":["17121616"]}]},{"name":"HKU Strategic Research Theme of Cancer Seed Fund for Collaboration","award":["T12-401\/13-R"],"award-info":[{"award-number":["T12-401\/13-R"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Magnesium (Mg) has been known to play vital roles in regulating growth and various metabolic processes. In recent years, the association between Mg and tumorigenesis has raised more and more attention. However, the effects of Mg on the progression of head and neck carcinoma (HNC), as well as the mechanism behind it, remain undefined. In this study, the roles of Mg in tumorigenic activities were tested in CAL27 and FaDu cells as well as in a xenograft tumor model in nude mice. We demonstrated that a moderate increase in extracellular Mg contributed to the proliferation, migration, and invasion of 2 HNC cell lines, while the addition of Mg in drinking water promoted the growth of xenograft tumors in mice without altering their serum Mg levels. Moreover, TRPM7, a major Mg transporter, was shown to be essential for the tumorigenic activities of HNC and the Mg-induced promotive effects on HNC cells and was further shown to be associated with the activation of AKT\/mTOR (mammalian target of rapamycin) signaling. In a preliminary clinical study, we determined the Mg ion concentrations in the stimulated saliva from 72 patients with nasopharynx carcinoma and 12 healthy individuals. Our data revealed that the salivary Mg levels of subjects with nasopharynx carcinoma were significantly higher than those of the healthy controls. This is correlated with our finding showing TRPM7 to be overexpressed in tumor tissues harvested from 9 patients with HNC. Therefore, we can conclude that salivary Mg level, within a certain range, could act as a risk factor for the progression of HNC, which involves the activation of AKT\/mTOR signaling pathways through the TRPM7 channel. The control of salivary Mg level and the intervention of TRPM7 should not be ignored during the study of HNC.<\/jats:p>","DOI":"10.1177\/0022034518813359","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T18:55:24Z","timestamp":1543949724000},"page":"304-312","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of Salivary Mg on Head and Neck Carcinoma via TRPM7"],"prefix":"10.1177","volume":"98","author":[{"given":"W.","family":"Qiao","sequence":"first","affiliation":[{"name":"Dental Materials Science, Applied Oral Sciences, Faculty of Dentistry, University of Hong Kong, Hong Kong, China"},{"name":"Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.M.","family":"Lan","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Hong Kong, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.X.","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, School of Public Health, Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9480-4637","authenticated-orcid":false,"given":"J.Y.K.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.W.Y.","family":"Lui","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.W.K.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.L.W.","family":"Kwong","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, University of Hong Kong, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, School of Public Health, Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.K.H.","family":"Tsoi","sequence":"additional","affiliation":[{"name":"Dental Materials Science, Applied Oral Sciences, Faculty of Dentistry, University of Hong Kong, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.P.","family":"Matinlinna","sequence":"additional","affiliation":[{"name":"Dental Materials Science, Applied Oral Sciences, Faculty of Dentistry, University of Hong Kong, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.X.","family":"Su","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Hong Kong, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"key":"bibr1-0022034518813359","doi-asserted-by":"crossref","unstructured":"Castiglioni S, Maier JA. 2011. 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