{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:21:20Z","timestamp":1793305280185,"version":"4.5.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T00:00:00Z","timestamp":1546992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Sunstar Inc. and Weimer pharma German"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>The purpose of this study was to determine the clinical, microbial, and radiographic effects of local minocycline combined with surgical treatment of peri-implantitis. Fifty patients with peri-implantitis were recruited, and surgical treatment with the local application of either minocycline or placebo ointment was performed. The application of minocycline was repeated with supragingival debridement at 1, 3, and 6 mo postoperatively. Plaque index, gingival index (GI), probing pocket depth (PPD), and bleeding\/suppuration on probing were measured at baseline and 1-, 3-, and 6-mo evaluations. The change in supporting bone level (SBL) measured with cone beam computed tomography was analyzed between baseline and 6 mo. Microbial analysis was performed with real-time polymerase chain reaction. Both groups exhibited improvements in clinical and radiographic measurements after surgical treatment. There was a significant difference in the changes of mean PPD between the test and control groups (2.68 \u00b1 1.73 and 1.55 \u00b1 1.86 mm, respectively, P = 0.039). The changes of mean GI and SBL differed significantly between the groups (\u0394GI: 0.83 \u00b1 0.60 and 0.40 \u00b1 0.68; \u0394SBL: 0.72 \u00b1 0.56 and 0.31 \u00b1 0.49 mm, respectively, P = 0.026 and 0.014). Treatment success rates (defined as PPD &lt;5 mm, absence of bleeding\/suppuration on probing, and no further bone loss) were 66.7% and 36.3% in the test and control groups, respectively. The count of red complex bacteria tended to decrease in both groups until 6 mo; however, no significant intergroup difference was found. None of the patients in the test group carried Porphyromonas gingivalis or Tannerella forsythia at 6 mo. These findings indicate that the repeated local delivery of minocycline combined with surgical treatment provides significant benefits in terms of clinical parameters and radiographic bone fill, with a higher treatment success rate in the short healing period (cris.nih.go.kr KCT0002844).<\/jats:p>","DOI":"10.1177\/0022034518818479","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T20:36:06Z","timestamp":1547066166000},"page":"288-295","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":90,"title":["Surgical Therapy of Peri-Implantitis with Local Minocycline: A 6-Month Randomized Controlled Clinical Trial"],"prefix":"10.1177","volume":"98","author":[{"given":"J.K.","family":"Cha","sequence":"first","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea"},{"name":"Department of Applied Life Science, BK21 PLUS Project, College of Dentistry, Yonsei University, Seoul, South Korea"},{"name":"Department of Mechanical Engineering, College of Engineering, Yonsei University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,1,9]]},"reference":[{"key":"bibr1-0022034518818479","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01631.x"},{"key":"bibr2-0022034518818479","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12155"},{"key":"bibr3-0022034518818479","first-page":"S286","volume-title":"Peri-implant diseases and conditions: consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-implant Diseases and Conditions","volume":"20","author":"Berglundh T","year":"2018"},{"key":"bibr4-0022034518818479","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515601961"},{"key":"bibr5-0022034518818479","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01277.x"},{"key":"bibr6-0022034518818479","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12588"},{"key":"bibr7-0022034518818479","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513504953"},{"key":"bibr8-0022034518818479","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000428"},{"key":"bibr9-0022034518818479","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01275.x"},{"key":"bibr10-0022034518818479","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00348.x"},{"key":"bibr11-0022034518818479","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2014suppl.g5.3"},{"key":"bibr12-0022034518818479","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12910"},{"key":"bibr13-0022034518818479","doi-asserted-by":"crossref","unstructured":"Isehed C, Holmlund A, Renvert S, Svenson B, Johansson I, Lundberg P. 2016. Effectiveness of enamel matrix derivative on the clinical and microbiological outcomes following surgical regenerative treatment of peri-implantitis: a randomized controlled trial. 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