{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:24:24Z","timestamp":1793381064938,"version":"4.5.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["#U54GM115371"],"award-info":[{"award-number":["#U54GM115371"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000139","name":"U.S. Environmental Protection Agency","doi-asserted-by":"publisher","award":["RD83559701"],"award-info":[{"award-number":["RD83559701"]}],"id":[{"id":"10.13039\/100000139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Alaska Native (AN) children experience one of the highest reported rates of severe early childhood caries (S-ECC). Serum vitamin D concentrations in AN childbearing women in the Yukon Kuskokwim Delta (YKD) region have decreased since the 1960s to currently low levels, related to a decrease in traditional marine diet. Recent studies suggest an association between prenatal vitamin D (25(OH)D) concentrations in mothers and S-ECC in their infants. We used independent t tests to analyze the influence of prenatal 25(OH)D levels in YKD AN mothers on S-ECC in their children using data collected in the Maternal Organics Monitoring Study (MOMS). Maternal 25(OH)D levels were assessed at prenatal visits and in cord blood. We queried electronic dental records to assess early childhood caries (ECC) status using highest decayed, missing, filled, primary teeth (dmft) scores at 12 to 59 mo of age. We examined prenatal and cord blood for 76 and 57 mother\/infant pairs, respectively. Children 12 to 35 mo of age with \u201cdeficient\u201d cord blood (25(OH)D &lt;30 nmol\/L) had a mean dmft score twice as high as children who were \u201cnondeficient\u201d at birth (9.3 vs. 4.7; P = 0.002). There was no significant difference in mean dmft scores for children aged 36 to 59 mo with deficient versus nondeficient cord blood 25(OH)D (10.9 vs. 8.7 P = 0.14). There was no significant difference in mean dmft scores for children aged 12 to 35 mo whose mothers had \u201csufficient\u201d versus \u201cinsufficient\u201d 25(OH)D during prenatal visits (9.0 vs. 7.4; P = 0.48). In this small sample, children with deficient vitamin D levels in cord blood had a dmft score at 12 to 35 mo 2-fold higher than children with nondeficient cord blood. Maternal 25(OH)D may influence the primary dentition, and improving vitamin D status in pregnant women might affect ECC rates in their infants.<\/jats:p>","DOI":"10.1177\/0022034519834518","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T17:10:41Z","timestamp":1552583441000},"page":"549-555","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["Association of Maternal Vitamin D Deficiency with Early Childhood Caries"],"prefix":"10.1177","volume":"98","author":[{"given":"R.","family":"Singleton","sequence":"first","affiliation":[{"name":"Alaska Native Tribal Health Consortium, Anchorage, AK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Day","sequence":"additional","affiliation":[{"name":"Alaska Native Tribal Health Consortium, Anchorage, AK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Alaska Native Tribal Health Consortium, Anchorage, AK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Schroth","sequence":"additional","affiliation":[{"name":"University of Manitoba, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Klejka","sequence":"additional","affiliation":[{"name":"Yukon Kuskokwim Health Corporation, Bethel, AK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Lenaker","sequence":"additional","affiliation":[{"name":"Southeast Alaska Regional Health Consortium, Sitka, AK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Berner","sequence":"additional","affiliation":[{"name":"Alaska Native Tribal Health Consortium, Anchorage, AK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"issue":"3","key":"bibr1-0022034519834518","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s13181-016-0562-8","volume":"12","author":"Anwar M","year":"2016","journal-title":"J Med Toxicol"},{"key":"bibr2-0022034519834518","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2006.04.026"},{"key":"bibr3-0022034519834518","first-page":"500","volume":"810","author":"Bischoff-Ferrari HA","year":"2014","journal-title":"Adv Exp Med Biol"},{"key":"bibr4-0022034519834518","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.2.447"},{"key":"bibr5-0022034519834518","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512444929"},{"issue":"37","key":"bibr6-0022034519834518","first-page":"1275","volume":"60","author":"Centers for Disease Control and Prevention","year":"2011","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr7-0022034519834518","doi-asserted-by":"publisher","DOI":"10.1111\/nure.12078"},{"key":"bibr8-0022034519834518","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-7325.1999.tb03268.x"},{"key":"bibr9-0022034519834518","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143769"},{"key":"bibr10-0022034519834518","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.139006"},{"key":"bibr11-0022034519834518","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.124644"},{"key":"bibr12-0022034519834518","doi-asserted-by":"publisher","DOI":"10.3945\/jn.115.223388"},{"key":"bibr13-0022034519834518","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2010.09.017"},{"key":"bibr14-0022034519834518","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2012.00544.x"},{"key":"bibr15-0022034519834518","unstructured":"Institute of Medicine Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Ross AC, Taylor CL, Yaktine AL, Del Valle HB, editors. 2010. 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