{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:05:56Z","timestamp":1793419556019,"version":"4.5.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.sagepub.com\/licence-information-for-chorus"}],"funder":[{"DOI":"10.13039\/501100001691","name":"japan society for the promotion of science","doi-asserted-by":"publisher","award":["(C):22592213 and 25463081"],"award-info":[{"award-number":["(C):22592213 and 25463081"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009029","name":"adaptable and seamless technology transfer program through target-driven r and d","doi-asserted-by":"publisher","award":["FS stage AS231Z01061G and AS242Z02645Q"],"award-info":[{"award-number":["FS stage AS231Z01061G and AS242Z02645Q"]}],"id":[{"id":"10.13039\/501100009029","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>While the prevalence of supernumerary teeth (ST) is high in permanent dentition, the etiology of ST in humans remains unclear. However, multiple murine models of ST have elaborated on dated mechanisms traditionally ascribed to ST etiology: one involves the rescue of rudimental teeth, and the second considers the contribution of odontogenic epithelial stem cells. It remains unclear whether these mechanisms of ST formation in mice are applicable to humans. The third dentition is usually regressed apoptotic\u2014that is, the teeth do not completely form in humans. Recently, it was suggested that ST result from the rescue of regression of the third dentition in humans. The present investigation evaluates the proportion of collected general ST cases that evinced a third dentition based on the clinical definition of ST derived from the third dentition. We also investigated the contribution of SOX2-positive odontogenic epithelial stem cells to ST formation in humans. We collected 215 general ST cases from 15,008 patients. We confirmed that the general characteristics of the collected ST cases were similar to the results from previous reports. Of the 215 cases, we narrowed our analysis to the 78 patients who had received a computed tomography scan. The frequency of ST considered to have been derived from the third dentition was 26 out of 78 cases. Evidence of a third dentition was especially apparent in the premolar region, was more common in men, and was more likely among patients with \u22653 ST. SOX2-positive odontogenic epithelial stem cells within the surrounding epithelial cells of developing ST were observed in non\u2013third dentition cases and not in third dentition cases. In conclusion, the third dentition is the main cause of ST in humans. The odontogenic epithelial stem cells may contribute to ST formation in cases not caused by a third dentition.<\/jats:p>","DOI":"10.1177\/0022034519858282","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T18:12:35Z","timestamp":1561486355000},"page":"968-974","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Third Dentition Is the Main Cause of Premolar Supernumerary Tooth Formation"],"prefix":"10.1177","volume":"98","author":[{"given":"H.","family":"Kiso","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mishima","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Murashima-Suginami","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kakeno","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Asai","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Tokita","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9546-9869","authenticated-orcid":false,"given":"R.","family":"Uozumi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sugai","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-8568","authenticated-orcid":false,"given":"H.","family":"Harada","sequence":"additional","affiliation":[{"name":"The Advanced Oral Health Science Research Center, Iwate Medical University, Iwate, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Dentistry and Health Sciences, Charles Sturt University, Orange, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"MacDougall","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Bessho","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"bibr1-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01111.x"},{"issue":"3","key":"bibr2-0022034519858282","first-page":"140","volume":"24","author":"Ardakani FE","year":"2007","journal-title":"Community Dent Health"},{"key":"bibr3-0022034519858282","doi-asserted-by":"publisher","DOI":"10.4317\/jced.51499"},{"key":"bibr4-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12160"},{"key":"bibr5-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1086\/521988"},{"key":"bibr6-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2013.06.008"},{"key":"bibr7-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1038\/nm861"},{"key":"bibr8-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.147.1.105"},{"key":"bibr9-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1047"},{"key":"bibr10-0022034519858282","volume-title":"Teeth","author":"Hillson S","year":"1986"},{"key":"bibr11-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1990.tb00803.x"},{"key":"bibr12-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2013.46"},{"key":"bibr13-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517720158"},{"key":"bibr14-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12095"},{"key":"bibr15-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1242\/dev.089599"},{"issue":"3","key":"bibr16-0022034519858282","doi-asserted-by":"crossref","first-page":"349","DOI":"10.4103\/ccd.ccd_31_18","volume":"9","author":"Khandelwal P","year":"2018","journal-title":"Contemp Clin Dent"},{"key":"bibr17-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096938"},{"key":"bibr18-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.535740"},{"key":"bibr19-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12418"},{"key":"bibr20-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37967"},{"key":"bibr21-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.01.017"},{"key":"bibr22-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1080\/15476278.2017.1332554"},{"key":"bibr23-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37763"},{"key":"bibr24-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12456"},{"key":"bibr25-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2000.tb00108.x"},{"key":"bibr26-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.05.148"},{"key":"bibr27-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.02.135"},{"key":"bibr28-0022034519858282","doi-asserted-by":"publisher","DOI":"10.2535\/ofaj1936.46.5_243"},{"key":"bibr29-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2004.00158.x"},{"key":"bibr30-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1038\/sj.dmfr.4600258"},{"key":"bibr31-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-263X.2002.00366.x"},{"key":"bibr32-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23515-y"},{"key":"bibr33-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2006.00791.x"},{"key":"bibr34-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2011.03.063"},{"key":"bibr35-0022034519858282","doi-asserted-by":"publisher","DOI":"10.5772\/52529"},{"key":"bibr36-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoms.2015.12.006"},{"key":"bibr37-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161067"},{"key":"bibr38-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20715"},{"key":"bibr39-0022034519858282","doi-asserted-by":"publisher","DOI":"10.1038\/srep14479"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034519858282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0022034519858282","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034519858282","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034519858282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:08:11Z","timestamp":1777496891000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0022034519858282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,25]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1177\/0022034519858282"],"URL":"https:\/\/doi.org\/10.1177\/0022034519858282","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,25]]}}}