{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:53:25Z","timestamp":1777812805237,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Postdental procedure bacteremia is common and troublesome. The comparative efficacy of multiple prophylactic interventions is unclear. We compared the efficacy of interventions for the prevention of postdental procedure bacteremia. We conducted a review of ClinicalKey, Cochrane CENTRAL, Embase, ProQuest, PubMed, ScienceDirect, Web of Science, and ClinicalTrials.gov from inception to December 4, 2018. Randomized controlled trials that evaluated prophylactic interventions for the prevention of postdental procedure bacteremia were eligible. The primary outcome was the incidence of postdental procedure bacteremia. A total of 24 trials were included with 2,147 participants. Our network meta-analysis demonstrated that intravenous administration of 1,000\/200 mg of amoxicillin\/clavulanate provided the least incidence of postdental procedure bacteremia among all the prophylactic interventions (odds ratio = 0.03, 95% CI = 0.00 to 0.63) as compared with the placebo\/controls. Oral 3 g of amoxicillin had the least incidence of postdental procedure bacteremia among all oral or topical forms of prophylactic interventions (odds ratio = 0.10, 95% CI = 0.02 to 0.44) as compared with the placebo\/controls. No serious adverse events, such as anaphylactic shock, mortality, and the development of antibiotic-resistant bacteria, were reported. None of the included subjects were of high risk of infectious endocarditis. Our network meta-analysis demonstrates that intravenous amoxicillin\/clavulanate and oral amoxicillin might be the best prophylactic interventions in preventing postdental procedure bacteremia among all the oral\/topical forms of interventions for the overall populations.<\/jats:p>","DOI":"10.1177\/0022034519870466","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T14:07:13Z","timestamp":1567174033000},"page":"1204-1210","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Prevention of Postdental Procedure Bacteremia: A Network Meta-analysis"],"prefix":"10.1177","volume":"98","author":[{"given":"B.S.","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, E-Da Hospital, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.Y.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dentistry, MacKay Memorial Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.K.","family":"Tu","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan"},{"name":"Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.C.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Landseed International Hospital, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Stubbs","sequence":"additional","affiliation":[{"name":"Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London, UK"},{"name":"Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, De Crespigny Park, London, UK"},{"name":"Positive Ageing Research Institute, Faculty of Health, Social Care and Education, Anglia Ruskin University, Chelmsford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.S.","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Beitou Branch, Tri-Service General Hospital; School of Medicine, National Defense Medical Center, Taipei, Taiwan"},{"name":"Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.C.","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri-Service General Hospital; School of Medicine, National Defense Medical Center, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri-Service General Hospital; School of Medicine, National Defense Medical Center, Taipei, Taiwan"},{"name":"Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.F.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada"},{"name":"Centre for Addiction & Mental Health (CAMH), Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1394-4567","authenticated-orcid":false,"given":"P.Y.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan"},{"name":"Institute for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.T.","family":"Lei","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, Rheumatology Disease, Department of Pediatrics, Mackay Memorial Hospital, Hsinchu, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.W.","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Prospect Clinic for Otorhinolaryngology and Neurology, Kaohsiung City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.T.","family":"Tseng","sequence":"additional","affiliation":[{"name":"Prospect Clinic for Otorhinolaryngology and Neurology, Kaohsiung City, Taiwan"},{"name":"WinShine Clinics in Specialty of Psychiatry, Kaohsiung City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4564-8727","authenticated-orcid":false,"given":"C.H.","family":"Chen","sequence":"additional","affiliation":[{"name":"Program in Translational Medicine, National Chung Hsing University, Taichung City, Taiwan"},{"name":"Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung City, Taiwan"},{"name":"Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,8,30]]},"reference":[{"key":"bibr1-0022034519870466","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195592"},{"key":"bibr2-0022034519870466","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124249"},{"key":"bibr3-0022034519870466","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-309102"},{"key":"bibr4-0022034519870466","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62007-9"},{"key":"bibr5-0022034519870466","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg286"},{"key":"bibr6-0022034519870466","doi-asserted-by":"publisher","DOI":"10.1016\/j.jebdp.2016.12.001"},{"key":"bibr7-0022034519870466","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl121"},{"issue":"6","key":"bibr8-0022034519870466","first-page":"410","volume":"53","author":"Groppo FC","year":"2005","journal-title":"Gen Dent"},{"key":"bibr9-0022034519870466","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv319"},{"key":"bibr10-0022034519870466","doi-asserted-by":"crossref","unstructured":"Higgins J, Green S. 2009. 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