{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:11:05Z","timestamp":1792077065549,"version":"4.4.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901042"],"award-info":[{"award-number":["81901042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970913"],"award-info":[{"award-number":["81970913"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>\n                    Stem cells play a critical role in bone regeneration. Multiple populations of skeletal stem cells have been identified in long bone, while their identity and functions in alveolar bone remain unclear. Here, we identified a quiescent leptin receptor\u2013expressing (LepR\n                    <jats:sup>+<\/jats:sup>\n                    ) cell population that contributed to intramembranous bone formation. Interestingly, these LepR\n                    <jats:sup>+<\/jats:sup>\n                    cells became activated in response to tooth extraction and generated the majority of the newly formed bone in extraction sockets. In addition, genetic ablation of LepR\n                    <jats:sup>+<\/jats:sup>\n                    cells attenuated extraction socket healing. The parabiosis experiments revealed that the LepR\n                    <jats:sup>+<\/jats:sup>\n                    cells in the healing sockets were derived from resident tissue rather than peripheral blood circulation. Further studies on the mechanism suggested that these LepR\n                    <jats:sup>+<\/jats:sup>\n                    cells were responsive to parathyroid hormone\/parathyroid hormone 1 receptor (PTH\/PTH1R) signaling. Collectively, we demonstrate that LepR\n                    <jats:sup>+<\/jats:sup>\n                    cells, a postnatal skeletal stem cell population, are essential for alveolar bone regeneration of extraction sockets.\n                  <\/jats:p>","DOI":"10.1177\/0022034520932834","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T18:20:56Z","timestamp":1593109256000},"page":"1279-1286","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":62,"title":["LepR-Expressing Stem Cells Are Essential for Alveolar Bone Regeneration"],"prefix":"10.1177","volume":"99","author":[{"given":"D.","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 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