{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T13:03:20Z","timestamp":1777813400281,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>\n                    The analysis of brain signal variability is a promising approach to understand pathological brain function related to chronic pain. This study investigates whether blood-oxygen-level\u2013dependent signal variability (BOLD\n                    <jats:sub>SV<\/jats:sub>\n                    ) in specific frequency bands is altered in temporomandibular disorder (TMD) and correlated to its clinical features. Twelve patients with chronic myofascial TMD and 24 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging. The BOLD\n                    <jats:sub>SV<\/jats:sub>\n                    was measured as the standard deviation of the BOLD time series at each voxel and compared between groups. We also examined the potential relationship between the BOLD\n                    <jats:sub>SV<\/jats:sub>\n                    and the catechol-\n                    <jats:italic>O<\/jats:italic>\n                    -methyltransferase (\n                    <jats:italic>COMT<\/jats:italic>\n                    ) Val\n                    <jats:sup>158<\/jats:sup>\n                    Met polymorphism. We assessed sensory-discriminative pain in the craniofacial region, pain sensitivity to sustained masseteric pain challenge, and TMD pain frequency for clinical correlation. Patients displayed reduced BOLD\n                    <jats:sub>SV<\/jats:sub>\n                    in the dorsolateral prefrontal cortex (dlPFC) as compared with HC in all frequency bands. In the slow-3 band, patients also showed reduced BOLD\n                    <jats:sub>SV<\/jats:sub>\n                    in the medial dorsal thalamus, primary motor cortex (M1), and primary somatosensory cortex (S1) and heightened BOLD\n                    <jats:sub>SV<\/jats:sub>\n                    in the temporal pole. Notably, we found a significant correlation between lower BOLD\n                    <jats:sub>SV<\/jats:sub>\n                    (slow-3) in the orofacial M1\/S1 regions and higher clinical pain (intensity\/area) and higher sensitivity of the masseter muscle pain. Moreover, lower BOLD\n                    <jats:sub>SV<\/jats:sub>\n                    (slow-3) in the dlPFC and ventrolateral PFC was associated with a higher TMD pain frequency. Participants who had the\n                    <jats:italic>COMT<\/jats:italic>\n                    <jats:sup>158<\/jats:sup>\n                    Met substitution exhibited lower BOLD\n                    <jats:sub>SV<\/jats:sub>\n                    in the dlPFC and higher BOLD\n                    <jats:sub>SV<\/jats:sub>\n                    in the temporal pole as compared with participants without the\n                    <jats:italic>COMT<\/jats:italic>\n                    <jats:sup>158<\/jats:sup>\n                    Met substitution. An increasing number of Met alleles was associated with lower dlPFC and greater temporal pole BOLD\n                    <jats:sub>SV<\/jats:sub>\n                    in both HC and TMD groups. Together, we demonstrated that chronic TMD patients exhibit aberrant BOLD\n                    <jats:sub>SV<\/jats:sub>\n                    in the top-down pain modulatory and sensorimotor circuits associated with their pain frequency and severity.\n                    <jats:italic>COMT<\/jats:italic>\n                    Val\n                    <jats:sup>158<\/jats:sup>\n                    Met polymorphism might affect clinical symptoms in association with regional brain signal variability, specifically involved in cognitive and emotional regulation of pain.\n                  <\/jats:p>","DOI":"10.1177\/0022034521994089","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:49:18Z","timestamp":1614127758000},"page":"714-722","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Aberrant Brain Signal Variability and COMT Genotype in Chronic TMD Patients"],"prefix":"10.1177","volume":"100","author":[{"given":"M.","family":"Lim","sequence":"first","affiliation":[{"name":"Headache and Orofacial Pain Effort (H.O.P.E.), Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA"},{"name":"Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.D.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Headache and Orofacial Pain Effort (H.O.P.E.), Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA"},{"name":"Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Headache and Orofacial Pain Effort (H.O.P.E.), Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA"},{"name":"Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.L.","family":"Ellingrod","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.F.","family":"DaSilva","sequence":"additional","affiliation":[{"name":"Headache and Orofacial Pain Effort (H.O.P.E.), Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA"},{"name":"Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA"},{"name":"Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.01.048"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.020"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.09.13"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.04.005"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001332"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099745"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520919384"},{"issue":"4","key":"e_1_3_2_9_1","first-page":"301","article-title":"Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique","volume":"6","author":"Dworkin SF","year":"1992","unstructured":"Dworkin SF, LeResche L. 1992. Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. 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