{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:41:25Z","timestamp":1784133685496,"version":"3.55.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["ZZ9603, 01ZZ0103, 01ZZ0403"],"award-info":[{"award-number":["ZZ9603, 01ZZ0103, 01ZZ0403"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"bundesministerium f\u00fcr bildung und forschung","doi-asserted-by":"publisher","award":["Competence Network Asthma\/COPD 01GI0881-0888"],"award-info":[{"award-number":["Competence Network Asthma\/COPD 01GI0881-0888"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>\n                    Although a potential link between periodontitis and cardiorespiratory fitness might provide a reasonable explanation for effects of tooth-related alterations seen on cardiometabolic diseases, evidence is currently limited. Thus, we investigated the association between clinically assessed periodontitis and cardiopulmonary exercise testing (CPET). Data from 2 independent cross-sectional population-based studies (5-y follow-up of the Study of Health in Pomerania [SHIP-1; N\u2009=\u20091,639] and SHIP-Trend-0 [ N\u2009=\u20092,439]) were analyzed. Participants received a half-mouth periodontal examination, and teeth were counted. CPET was based on symptom limited-exercise tests on a bicycle ergometer. Associations of periodontitis parameters with CPET parameters were analyzed by confounder-adjusted multivariable linear regression. In the total sample, mean pocket probing depth (PPD), mean clinical attachment levels, and number of teeth were consistently associated with peak oxygen uptake (peakVO\n                    <jats:sub>2<\/jats:sub>\n                    ) and exercise duration in both studies, even after restriction to cardiorespiratory healthy participants. Statistically significant associations with oxygen uptake at anaerobic threshold (VO\n                    <jats:sub>2<\/jats:sub>\n                    @AT), slope of the efficiency of ventilation in removing carbon dioxide, and peak oxygen pulse (V\u00c9\/VCO\n                    <jats:sub>2<\/jats:sub>\n                    slope) occurred. Further, interactions with age were identified, such that mainly older individuals with higher levels of periodontal disease severity were associated with lower peakVO\n                    <jats:sub>2<\/jats:sub>\n                    . Restricted to never smokers, associations with mean clinical attachment levels and the number of teeth mostly diminished, while associations of mean PPD with peakVO\n                    <jats:sub>2<\/jats:sub>\n                    , VO\n                    <jats:sub>2<\/jats:sub>\n                    @AT, V\u00c9\/VCO\n                    <jats:sub>2<\/jats:sub>\n                    slope, and exercise duration in SHIP-1 and SHIP-Trend-0 were confirmed. In SHIP-1, mean peakVO\n                    <jats:sub>2<\/jats:sub>\n                    was 1,895\u2009mL\/min in participants with a mean PPD of 1.6\u2009mm and 1,809\u2009mL\/min in participants with a mean PPD of 3.7\u2009mm. To conclude, only mean PPD reflecting current disease severity was consistently linked to cardiorespiratory fitness in 2 cross-sectional samples of the general population. If confirmed in well-designed large-scale longitudinal studies, the association between periodontitis and cardiorespiratory fitness might provide a biologically plausible mechanism linking periodontitis with cardiometabolic diseases.\n                  <\/jats:p>","DOI":"10.1177\/0022034521995428","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T07:20:01Z","timestamp":1614756001000},"page":"824-832","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Periodontitis Is Related to Exercise Capacity: Two Cross-sectional Studies"],"prefix":"10.1177","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6541-3127","authenticated-orcid":false,"given":"B.","family":"Holtfreter","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Stubbe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B, Cardiology, Pneumology, Weaning, Infectious Diseases, Intensive Care Medicine, University Medicine Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gl\u00e4ser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Vivantes Kliniken Berlin, Neuk\u00f6lln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8220-8926","authenticated-orcid":false,"given":"J.","family":"Trabandt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Vivantes Kliniken Berlin, Neuk\u00f6lln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"V\u00f6lzke","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine, SHIP\/Clinical-Epidemiological Research, University Medicine Greifswald, Greifswald, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ewert","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B, Cardiology, Pneumology, Weaning, Infectious Diseases, Intensive Care Medicine, University Medicine Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kocher","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ittermann","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine, SHIP\/Clinical-Epidemiological Research, University Medicine Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Sch\u00e4per","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B, Cardiology, Pneumology, Weaning, Infectious Diseases, Intensive Care Medicine, University Medicine Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"key":"bibr1-0022034521995428","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2008.02036.x"},{"key":"bibr2-0022034521995428","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12425"},{"key":"bibr3-0022034521995428","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201610-2089OC"},{"key":"bibr4-0022034521995428","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077441"},{"key":"bibr5-0022034521995428","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2017.224"},{"key":"bibr6-0022034521995428","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12183"},{"issue":"3","key":"bibr7-0022034521995428","first-page":"e436","volume":"16","author":"Gay-Escoda C","year":"2010","journal-title":"Med Oral Patol Oral Cir 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