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An individual\u2019s host response, triggered by a dysbiotic subgingival biofilm, has been reported as a contributor to the tissue destruction, although mechanisms of this response and contributions to such disease remain poorly understood. Nonsurgical treatment has resulted in positive clinical responses for both localized (now molar-incisor pattern) and generalized forms of grade C periodontitis, especially when adjunctive systemic antibiotics are used. Nonsurgical treatment may also affect host responses, although mechanisms leading to significant changes in this response remain unclear. Significant effects on inflammatory response to antigens\/bacteria have been described posttreatment, but evidence for long-term effects remains limited. Nonsurgical treatment in these individuals may also modulate a variety of host markers in serum\/plasma and gingival crevicular fluid along with clinical parameter improvements. The impact of other adjuncts to nonsurgical treatment focusing on controlling exacerbated immunoinflammatory responses needs to be further explored in grade C periodontitis in young individuals. Recent evidence suggests that nonsurgical treatment with adjunctive laser therapy may modulate host and microbial responses in those subjects, at least in the short term. Available evidence, while very heterogeneous (including variations in disease definition and study designs), does not provide clear conclusions on this topic yet provides important insights for future studies. In this review, studies within the past decade evaluating the impact of nonsurgical treatment on systemic\/local host responses in young individuals with grade C periodontitis, as well as long-term clinical responses posttreatment, will be critically appraised and discussed.<\/jats:p>","DOI":"10.1177\/00220345221148161","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T12:36:13Z","timestamp":1676723773000},"page":"473-488","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Impact of Treatment on Host Responses in Young Individuals with Periodontitis"],"prefix":"10.1177","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6928-8522","authenticated-orcid":false,"given":"L.S.","family":"Branco-de-Almeida","sequence":"first","affiliation":[{"name":"Post Graduate Program in Dentistry, School of Dentistry, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.M.","family":"Velsko","sequence":"additional","affiliation":[{"name":"Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.C.V.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Post Graduate Program in Dentistry, School of Dentistry, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.C.G.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Division of Periodontology, Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0948-1667","authenticated-orcid":false,"given":"L.M.","family":"Shaddox","sequence":"additional","affiliation":[{"name":"Division of Periodontology, Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,18]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070513"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516631973"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.170165"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13032"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12345"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12107"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12169"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13046"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12001"},{"issue":"3","key":"e_1_3_2_12_1","first-page":"258","article-title":"Local and plasma biomarker profiles in localized aggressive periodontitis","volume":"2","author":"Branco-de-Almeida LS","year":"2017","unstructured":"Branco-de-Almeida LS, Cruz-Almeida Y, Gonzalez-Marrero Y, Huang H, Aukhil I, Harrison P, Wallet SM, Shaddox LM. 2017. 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