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However, the physiological role of GFs is not restricted to the production and remodeling of the extracellular matrix. GFs also act as sentinel cells that modulate the immune response to oral pathogens invading the gingival tissue. As an important \u201cnonclassical\u201d component of the innate immune system, GFs respond to bacteria and damage-related signals by producing cytokines, chemokines, and other inflammatory mediators. Although the activation of GFs supports the elimination of invading bacteria and the resolution of inflammation, their uncontrolled or excessive activation may promote inflammation and bone destruction. This occurs in periodontitis, a chronic inflammatory disease of the periodontium initiated and sustained by dysbiosis. In the inflamed gingival tissue, GFs acquire imprinted proinflammatory phenotypes that promote the growth of inflammophilic pathogens, stimulate osteoclastogenesis, and contribute to the chronicity of inflammation. In this review, we discuss the biological functions of GFs in healthy and inflamed gingival tissue, highlighting recent studies that provide insight into their role in the pathogenesis of periodontal diseases. We also draw parallels with the recently discovered fibroblast populations identified in other tissues and their roles in health and disease. This knowledge should be used in future studies to discover more about the role of GFs in periodontal diseases, especially chronic periodontitis, and to identify therapeutic strategies targeting their pathological interactions with oral pathogens and the immune system.<\/jats:p>","DOI":"10.1177\/00220345231151921","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T07:14:21Z","timestamp":1678259661000},"page":"489-496","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":158,"title":["The Role of Gingival Fibroblasts in the Pathogenesis of Periodontitis"],"prefix":"10.1177","volume":"102","author":[{"given":"A.","family":"Wielento","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.B.","family":"Lagosz-Cwik","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Potempa","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krak\u00f3w, Poland"},{"name":"Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9472-850X","authenticated-orcid":false,"given":"A.M.","family":"Grabiec","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"bibr1-00220345231151921","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2007.01041.x"},{"key":"bibr2-00220345231151921","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.07.007"},{"key":"bibr3-00220345231151921","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-241"},{"key":"bibr4-00220345231151921","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2007.03.001"},{"key":"bibr5-00220345231151921","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.03.009"},{"key":"bibr6-00220345231151921","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2016.09.020"},{"key":"bibr7-00220345231151921","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62810"},{"key":"bibr8-00220345231151921","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00546-5"},{"key":"bibr9-00220345231151921","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516686745"},{"key":"bibr10-00220345231151921","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1263-7"},{"key":"bibr11-00220345231151921","doi-asserted-by":"crossref","unstructured":"Crowley T, Buckley CD, Clark AR. 2018. 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