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This is crucial as compelling evidence from human and animal model studies has demonstrated that sex and gender influence health, molecular and cellular processes, and response and predisposition to disease. The present scoping review aims to provide a synthesis of sex differences in oral diseases, ranging from periodontal disease to orofacial pain conditions, from risk of caries development to apical periodontitis. Overall, findings from this review further support a role for sexual dimorphism influencing disease predisposition and\/or progression in oral diseases. Of note, this review also highlights the lack of consideration of additional factors such as gender and other psychosocial and external factors potentially influencing oral health and disease. New conceptual frameworks capable of capturing multiple fundamental domains and measurements should be developed in clinical and preclinical studies to inform sex-based individualized preventive and treatment strategies.<\/jats:p>","DOI":"10.1177\/00220345231197143","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T17:03:29Z","timestamp":1700067809000},"page":"1395-1416","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Sex as a Biological Variable in Oral Diseases: Evidence and Future Prospects"],"prefix":"10.1177","volume":"102","author":[{"given":"L.","family":"Sangalli","sequence":"first","affiliation":[{"name":"College of Dental Medicine\u2013Illinois, Midwestern University, Downers Grove, IL, 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