{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:43:37Z","timestamp":1788903817084,"version":"build-2803163510"},"reference-count":41,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100002569","name":"American Association of Endodontists Foundation","doi-asserted-by":"publisher","award":["44096"],"award-info":[{"award-number":["44096"]}],"id":[{"id":"10.13039\/100002569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>\n                    Odontogenic pain can be debilitating, and nonopioid analgesic options are limited. This randomized placebo-controlled clinical trial aimed to assess the effectiveness and safety of cannabidiol (CBD) as an analgesic for patients with emergency acute dental pain. Sixty-one patients with moderate to severe toothache were randomized into 3 groups: CBD10 (CBD 10 mg\/kg), CBD20 (CBD 20 mg\/kg), and placebo. We administered a single dose of respective oral solution and monitored the subjects for 3 h. The primary outcome measure was the numerical pain differences using a visual analog scale (VAS) from baseline within and among the groups. Secondary outcome measures included ordinal pain intensity differences, the onset of significant pain relief, maximum pain relief, changes in bite force within and among the groups, psychoactive effects, mood changes, and other adverse events. Both CBD groups resulted in significant VAS pain reduction compared to their baseline and the placebo group, with a maximum median VAS pain reduction of 73\u201377% from baseline pain at the 180-min time point (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05). CBD20 experienced a faster onset of significant pain relief than CBD10 (15 versus 30 min after drug administration), and both groups reached maximum pain relief at 180-min. Number needed to treat was 3.1 for CBD10 and 2.4 for CBD20. Intragroup comparisons showed a significant increase in bite forces in both CBD groups (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05) but not in the placebo group (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &gt; 0.05). CBD20 resulted in a significant difference in mean percent bite force change in the 90- and 180-min time points compared to the placebo group (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05). Compared to placebo, sedation, diarrhea, and abdominal pain were significantly associated with the CBD groups (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05). There were no other significant psychoactive or mood change effects. This randomized trial provides the first clinical evidence that oral CBD can be an effective and safe analgesic for dental pain.\n                  <\/jats:p>","DOI":"10.1177\/00220345231200814","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T14:36:36Z","timestamp":1698849396000},"page":"235-242","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Cannabidiol as an Alternative Analgesic for Acute Dental Pain"],"prefix":"10.1177","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3136-378X","authenticated-orcid":false,"given":"V.","family":"Chrepa","sequence":"first","affiliation":[{"name":"UTHealth San Antonio, School of Dentistry, San Antonio, TX, USA"},{"name":"Rutgers School of Dental Medicine, Newark, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Villasenor","sequence":"additional","affiliation":[{"name":"University of Texas at San Antonio, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8865-2970","authenticated-orcid":false,"given":"A.","family":"Mauney","sequence":"additional","affiliation":[{"name":"University of Texas at San Antonio, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Kotsakis","sequence":"additional","affiliation":[{"name":"UTHealth San Antonio, School of Dentistry, San Antonio, TX, USA"},{"name":"Rutgers School of Dental Medicine, Newark, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Macpherson","sequence":"additional","affiliation":[{"name":"University of Texas at San Antonio, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.09.006"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2016.11.030"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet127"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2016.1135"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12117"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2019.1685298"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(03)00176-3"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2018.08.019"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001386"},{"issue":"3","key":"e_1_3_2_11_1","article-title":"Single dose oral ibuprofen for acute postoperative pain in adults","volume":"2009","author":"Derry C","year":"2009","unstructured":"Derry C, Derry S, Moore RA, McQuay HJ. 2009. 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