{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:10:29Z","timestamp":1794003029836,"version":"4.8.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE025659"],"award-info":[{"award-number":["DE025659"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE029808"],"award-info":[{"award-number":["DE029808"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>\n                    Periodontal mesenchymal stem cells (MSCs) play a crucial role in maintaining periodontium homeostasis and in tissue repair. However, little is known about how periodontal MSCs in vivo respond under periodontal disease conditions, posing a challenge for periodontium tissue regeneration. In this study, Gli1 was used as a periodontal MSC marker and combined with a Gli1-cre ERT2 mouse model for lineage tracing to investigate periodontal MSC fate in an induced periodontitis model. Our findings show significant changes in the number and contribution of Gli1\n                    <jats:sup>+<\/jats:sup>\n                    MSCs within the inflamed periodontium. The number of Gli1\n                    <jats:sup>+<\/jats:sup>\n                    MSCs that contributed to periodontal ligament homeostasis decreased in the periodontitis-induced teeth. While the proliferation of Gli1\n                    <jats:sup>+<\/jats:sup>\n                    MSCs had no significant difference between the periodontitis and the control groups, more Gli1\n                    <jats:sup>+<\/jats:sup>\n                    MSCs underwent apoptosis in diseased teeth. In addition, the number of Gli1\n                    <jats:sup>+<\/jats:sup>\n                    MSCs for osteogenic differentiation decreased during the progression of periodontitis. Following tooth extraction, the contribution of Gli1\n                    <jats:sup>+<\/jats:sup>\n                    MSCs to the tooth socket repair was significantly reduced in the periodontitis-induced teeth. Collectively, these findings indicate that the function of Gli1\n                    <jats:sup>+<\/jats:sup>\n                    MSCs in periodontitis was compromised, including reduced contribution to periodontium homeostasis and impaired injury response.\n                  <\/jats:p>","DOI":"10.1177\/00220345231220915","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T05:22:31Z","timestamp":1706505751000},"page":"279-288","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Gli1\n                    <sup>+<\/sup>\n                    Periodontal Mesenchymal Stem Cells in Periodontitis"],"prefix":"10.1177","volume":"103","author":[{"given":"Y.","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Texas A&M University School of Dentistry, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Texas A&M University School of Dentistry, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.K.H.","family":"Svoboda","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Texas A&M University School of Dentistry, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.A.","family":"Opperman","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Texas A&M University School of Dentistry, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.B.","family":"Ruest","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Texas A&M University School of Dentistry, Dallas, TX, 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"bibr1-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.09.024"},{"key":"bibr2-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.23101"},{"key":"bibr3-00220345231220915","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17113931"},{"key":"bibr4-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1038\/nri3785"},{"key":"bibr5-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/615486"},{"key":"bibr6-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1242\/dev.201203"},{"key":"bibr7-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12209"},{"key":"bibr8-00220345231220915","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21145169"},{"key":"bibr9-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.12.035"},{"key":"bibr10-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12911"},{"key":"bibr11-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.02.012"},{"key":"bibr12-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c09420"},{"key":"bibr13-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12810"},{"key":"bibr14-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.06.006"},{"key":"bibr15-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2019.12.011"},{"key":"bibr16-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513493434"},{"key":"bibr17-00220345231220915","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054599"},{"key":"bibr18-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1177\/00220345221106921"},{"key":"bibr19-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02171-2"},{"key":"bibr20-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb00849.x"},{"key":"bibr21-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13645"},{"key":"bibr22-00220345231220915","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2019.0031"},{"key":"bibr23-00220345231220915","volume":"42","author":"Tonetti 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