{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:36:13Z","timestamp":1793900173290,"version":"4.8.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071086"],"award-info":[{"award-number":["82071086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Province Capability Improvement Project through Science, Technology and Education-Jiangsu Provincial Research Hospital Cultivation Unit","award":["YJXYYJSDW4"],"award-info":[{"award-number":["YJXYYJSDW4"]}]},{"name":"Jiangsu Provincial Medical Innovation Center","award":["CXZX202227"],"award-info":[{"award-number":["CXZX202227"]}]},{"name":"Project of Basic Science Research in Higher Education Institutions of Jiangsu Province","award":["23KJA320002"],"award-info":[{"award-number":["23KJA320002"]}]},{"name":"Jiangsu Provincial Key R&D Programme","award":["BE2023835"],"award-info":[{"award-number":["BE2023835"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>\n                    A ligature-induced periodontitis model was established in wild-type and CD146\n                    <jats:sup>CreERT2<\/jats:sup>\n                    ; Rosa\n                    <jats:sup>tdTomato<\/jats:sup>\n                    mice to explore the function of pericytes in alveolar bone formation. We found that during periodontitis progression and periodontal wound healing, CD146\n                    <jats:sup>+<\/jats:sup>\n                    \/NG2\n                    <jats:sup>+<\/jats:sup>\n                    pericytes were enriched in the periodontal tissue areas, which could migrate to the alveolar bone surface and colocalize with ALP\n                    <jats:sup>+<\/jats:sup>\n                    \/OCN\n                    <jats:sup>+<\/jats:sup>\n                    osteoblasts. Chemokine C-X-C motif receptor 4 (CXCR4) inhibition using AMD3100 blocked CD146-Cre\n                    <jats:sup>+<\/jats:sup>\n                    pericyte migration and osteogenesis, as well as further exacerbated periodontitis-associated bone loss. Next, primary pericytes were sorted out by magnetic-activated cell sorting and demonstrated that C-X-C motif chemokine ligand 12 (CXCL12) promotes pericyte migration and osteogenesis via CXCL12-CXCR4-Rac1 signaling. Finally, the local administration of an adeno-associated virus for Rac1 overexpression in NG2\n                    <jats:sup>+<\/jats:sup>\n                    pericytes promotes osteoblast differentiation of pericytes and increases alveolar bone volume in periodontitis. Thus, our results provided the evidence that pericytes may migrate and osteogenesis via the CXCL12-CXCR4-Rac1 axis during the pathological process of periodontitis.\n                  <\/jats:p>","DOI":"10.1177\/00220345241244687","type":"journal-article","created":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T02:42:56Z","timestamp":1717209776000},"page":"723-733","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["The Role of Pericyte Migration and Osteogenesis in Periodontitis"],"prefix":"10.1177","volume":"103","author":[{"given":"Y.","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Basic Science of Stomatology, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China"},{"name":"Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, China"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, 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