{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:57:33Z","timestamp":1777813053413,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100010903","name":"Key Programme","doi-asserted-by":"publisher","award":["2018YFE0202200"],"award-info":[{"award-number":["2018YFE0202200"]}],"id":[{"id":"10.13039\/501100010903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>\n                    Bone aging and decreased autophagic activity are related but poorly explored in the jawbone. This study aimed to characterize the aging jawbones and jawbone-derived stromal cells (JBSCs) and determine the role of autophagy in jawbone mass decline. We observed that the jawbones of older individuals and mice exhibited similar age-related bone loss. Furthermore, leptin receptor (LepR)\u2013lineage cells served as the primary source for in vitro cultured and expanded JBSCs, referred to as LepR-Cre\n                    <jats:sup>+<\/jats:sup>\n                    \/JBSCs. RNA-sequencing data from the jawbones and LepR-Cre\n                    <jats:sup>+<\/jats:sup>\n                    \/JBSCs showed the upregulated expression of the phosphoinositide 3-kinase (PI3K)\/protein kinase B (AKT)\/mammalian target of rapamycin (mTOR) pathway during aging. Through single-cell transcriptomics, we identified a decrease in the proportion of osteogenic lineage cells and the activation of the PI3K\/AKT pathway in LepR-lineage cells in aging bone tissues. Reduced basal autophagic activity, diminished autophagic flux, and decreased osteogenesis occurred in the jawbones and LepR-Cre\n                    <jats:sup>+<\/jats:sup>\n                    \/JBSCs from older mice (O-mice; O-JBSCs). Pharmacologic and constitutive autophagy activation alleviated the impaired osteogenesis in O-JBSCs. In addition, the suppression of mTOR-induced autophagy improved the aging phenotype of O-JBSCs. The activation of autophagy in LepR-Cre\n                    <jats:sup>+<\/jats:sup>\n                    \/JBSCs using chemical autophagic activators reduced the alveolar bone resorption in O-mice. Therefore, our study demonstrated that ATG molecules and pathways are crucial in jawbone aging, providing novel approaches to understanding age-related jawbone loss.\n                  <\/jats:p>","DOI":"10.1177\/00220345241264810","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T05:54:47Z","timestamp":1724651687000},"page":"1028-1038","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Autophagy Regulates Age-Related Jawbone Loss via LepR\n                    <sup>+<\/sup>\n                    Stromal Cells"],"prefix":"10.1177","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-2004","authenticated-orcid":false,"given":"B.","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Oral Implantology & Department of Oral and Maxillofacial Surgery, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology & Department of Oral and Maxillofacial Surgery, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology & Department of Oral and Maxillofacial Surgery, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology & Department of Oral and 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