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However, its involvement in host inflammation remains elusive. Here, we demonstrate that loss of m\n                    <jats:sup>6<\/jats:sup>\n                    Am methyltransferase phosphorylated CTD interacting factor 1 (PCIF1) attenuates periodontal inflammation in whole-body and myeloid lineage\u2013specific knockout mouse models. Pcif1 deletion inhibits macrophage phagocytosis and migration through m\n                    <jats:sup>6<\/jats:sup>\n                    Am-Csf1r signaling. In addition, colony-stimulating factor-1 receptor (CSF1R) is identified as a potential target for the treatment of periodontitis. We thus reveal a previously unrecognized role for PCIF1-mediated m\n                    <jats:sup>6<\/jats:sup>\n                    Am modification in governing macrophage responses and periodontal inflammation.\n                  <\/jats:p>","DOI":"10.1177\/00220345241271078","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T03:49:57Z","timestamp":1726631397000},"page":"1130-1140","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["m\n                    <sup>6<\/sup>\n                    Am Methyltransferase PCIF1 Regulates Periodontal Inflammation"],"prefix":"10.1177","volume":"103","author":[{"given":"W.","family":"Song","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 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