{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:44:36Z","timestamp":1793814276835,"version":"4.6.1"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["tsqn202211327"],"award-info":[{"award-number":["tsqn202211327"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021QH241"],"award-info":[{"award-number":["ZR2021QH241"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023YFC2506300"],"award-info":[{"award-number":["2023YFC2506300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82320108004"],"award-info":[{"award-number":["82320108004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\n                    H\n                    <jats:sub>2<\/jats:sub>\n                    S, as a typical metabolite of periodontal pathogens, exhibits a clear positive correlation with the occurrence and development of periodontitis. H\n                    <jats:sub>2<\/jats:sub>\n                    S at physiological concentrations can regulate many biological processes. However, excess H\n                    <jats:sub>2<\/jats:sub>\n                    S in the periodontal pocket can trigger secretion of proinflammatory cytokines, cause oxidative stress, and result in mitochondrial damage and cell death in human gingival fibroblasts, exacerbating periodontitis development and periodontal tissue destruction. Worse, H\n                    <jats:sub>2<\/jats:sub>\n                    S facilitates bacteria survival and proliferation by maintaining bacterial redox balance and enhancing antibiotic resistance. Unfortunately, scavenging H\n                    <jats:sub>2<\/jats:sub>\n                    S during periodontitis treatment is usually ignored. Herein, a kind of hyaluronic acid methacryloyl\/ZnO (HMZ) composite hydrogel with an H\n                    <jats:sub>2<\/jats:sub>\n                    S-scavenging ability was prepared to enhance periodontitis treatment. The HMZ hydrogel possessed good injectability and cytocompatibility and was able to remove H\n                    <jats:sub>2<\/jats:sub>\n                    S by a reaction with ZnO. As a result, the HMZ hydrogel was able to increase cell viability from 13% to 120% for human gingival fibroblasts and 22% to 94% for human periodontal ligament fibroblasts at 48 h, restore mitochondrial homeostasis, and alleviate cGAS-STING signaling pathway\u2013mediated inflammation. Meanwhile, the HMZ hydrogel showed satisfactory antibacterial properties and efficiency of plaque biofilm removal. The in vivo results further confirmed that HMZ hydrogel decreased the concentration of H\n                    <jats:sub>2<\/jats:sub>\n                    S within the periodontal pocket from 0.7 to 0.8 mM to the normal level (0.3 to 0.4 mM), killed the bacteria in the periodontal tissues, inhibited osteoclast activity, relieved excess inflammation, and decreased the vertical distance between the cementoenamel junction and the alveolar bone crest from 1,175 \u00b5m to 798 \u00b5m on the 7th day and from 1,075 \u00b5m to 693 \u00b5m on the 14th day, achieving efficient periodontal bone regeneration. In brief, an H\n                    <jats:sub>2<\/jats:sub>\n                    S scavenging-based promising strategy was developed to enhance the therapeutic efficiency of periodontitis.\n                  <\/jats:p>","DOI":"10.1177\/00220345241291540","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T08:38:29Z","timestamp":1733301509000},"page":"172-182","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["H\n                    <sub>2<\/sub>\n                    S-Scavenging Hydrogel Alleviating Mitochondria Damage to Control Periodontitis"],"prefix":"10.1177","volume":"104","author":[{"given":"C.","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Periodontology & Tissue Engineering and Regeneration, School and Hospital of Stomatology, Shandong University, Jinan, Shandong, China"},{"name":"Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Periodontology & Tissue Engineering and Regeneration, School and Hospital of Stomatology, Shandong University, Jinan, Shandong, China"},{"name":"Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bianco","sequence":"additional","affiliation":[{"name":"CNRS, Immunology, Immunopathology and Therapeutic Chemistry, University of Strasbourg, ISIS, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-5480","authenticated-orcid":false,"given":"S.","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Periodontology & Tissue Engineering and Regeneration, School and Hospital of Stomatology, Shandong University, Jinan, Shandong, China"},{"name":"Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Periodontology & Tissue Engineering and Regeneration, School and Hospital of Stomatology, Shandong University, Jinan, Shandong, China"},{"name":"Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, 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