{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:57Z","timestamp":1792787637973,"version":"4.5.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Science and Technology Program for Overseas Students in Sichuan Province","award":["2021-29-1"],"award-info":[{"award-number":["2021-29-1"]}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2021YFSY0011"],"award-info":[{"award-number":["2021YFSY0011"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    is one of the major pathogens of chronic periodontitis.\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    can cause systemic inflammation, amyloid \u03b2 protein deposition, and hyperphosphorylation of tau protein, leading to Alzheimer\u2019s disease (AD)\u2013like lesions.\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    oral infection causes gut microbiota alteration, gut barrier dysfunction, and intestinal immune response and inflammation. The microbiota-gut-brain axis has a potential role in the pathogenesis of AD. Whether\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    affects AD-like lesions via the gut-brain axis needs more study. In this study, orally administered\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    induced alveolar resorption, intestinal barrier impairment, and AD-like lesions. Oral infection with\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    induced oral and gut microflora dysbiosis, imbalance of the tryptophan metabolism pathway of gut microbiota, and elevated levels of 3-hydroxykynurenine in the sera and hippocampi. The key metabolite, 3-hydroxykynurenine, suppressed\n                    <jats:italic>Bcl2<\/jats:italic>\n                    gene expression, leading to neuronal apoptosis and promoting AD-like lesions in vivo and in vitro. These findings suggest that\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    can induce AD pathogenesis through the gut-brain axis, providing new ideas for the prevention and treatment of AD.\n                  <\/jats:p>","DOI":"10.1177\/00220345241303141","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T23:41:06Z","timestamp":1738712466000},"page":"439-448","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["<i>Porphyromonas gingivalis<\/i>\n                    Induces Disturbance of Kynurenine Metabolism Through the Gut-Brain Axis: Implications for Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9887-5662","authenticated-orcid":false,"given":"H.","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for 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