{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:43:01Z","timestamp":1793367781887,"version":"4.5.0"},"reference-count":62,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T00:00:00Z","timestamp":1738454400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T00:00:00Z","timestamp":1738454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100016036","name":"health~holland","doi-asserted-by":"publisher","award":["LSHM18009-H008"],"award-info":[{"award-number":["LSHM18009-H008"]}],"id":[{"id":"10.13039\/100016036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>\n                    It has been questioned whether\n                    <jats:italic toggle=\"yes\">Streptococcus mutans<\/jats:italic>\n                    can still be considered the major etiological agent for caries. The main argument is that most evidence has been based on single-species identification. The composition of the oral microbiome was not analyzed. This systemic review aims to assess the prevalence and abundance of\n                    <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                    in caries-active (CA) and caries-free (CF) subjects based on clinical studies in which the microbiome was investigated. Three databases (PubMed, Cochrane, Embase) were searched until May 22, 2023, for eligible publications that included CA and CF subjects and reported the detection of both\n                    <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                    and the oral microbial community, using DNA-based methods. The clinical and microbial outcomes were summarized and further analyzed using a random-effects model. Of 22 eligible studies, 3 were excluded due to the high risk of bias. In the remaining 19 studies, 16 reported the prevalence of\n                    <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                    , 11 reported its relative abundance, and 8 reported both parameters. The prevalence of\n                    <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                    in CA was either similar to (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 4) or higher than (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 12) the CF group. The reported relative abundance in CA was higher than CF in all 11 studies, although the values varied from 0.001% to 5%. Meta-analysis confirmed the significance of these findings. The summary of microbial community data did not reveal other caries-associated bacterial genera\/species than\n                    <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                    . In conclusion, the collected evidence based on microbiome studies suggests a strong association between the prevalence and abundance of\n                    <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                    and caries experience. While the cariogenic role of\n                    <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                    in the oral ecosystem should be recognized, its actual function warrants further exploration.\n                  <\/jats:p>","DOI":"10.1177\/00220345241303880","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T01:00:46Z","timestamp":1738544446000},"page":"594-603","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":62,"title":["<i>Streptococcus mutans<\/i>\n                    and Caries: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9611-1391","authenticated-orcid":false,"given":"D.","family":"Mazurel","sequence":"first","affiliation":[{"name":"Department of Preventive Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, Noord-Holland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1155-1989","authenticated-orcid":false,"given":"B.W.","family":"Brandt","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, Noord-Holland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Boomsma","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, Noord-Holland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Crielaard","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, Noord-Holland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4212-9606","authenticated-orcid":false,"given":"M.","family":"Lagerweij","sequence":"additional","affiliation":[{"name":"Department of Cariology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, Noord-Holland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.A.M.","family":"Exterkate","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, Noord-Holland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3706-1678","authenticated-orcid":false,"given":"D.M.","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, Noord-Holland, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,2]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01410-07"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.01202-20"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1998.tb01933.x"},{"key":"e_1_3_2_5_1","unstructured":"American Academy of Pediatric Dentistry. 2022. 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