{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:12:59Z","timestamp":1793045579613,"version":"4.5.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Agency for the Promotion of Science and Technology, Argentina","award":["ANPCyT, PICT 2017-0361"],"award-info":[{"award-number":["ANPCyT, PICT 2017-0361"]}]},{"name":"Argentinean National Research Council","award":["PIP 11220150100251CO"],"award-info":[{"award-number":["PIP 11220150100251CO"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>\n                    The stability of messenger RNA (mRNA) is controlled by proteins that bind to adenosine-uridine\u2013rich sequences (AREs) in their 3\u2032 untranslated regions (3\u2032UTR), known as AU-binding proteins. One of these proteins is tristetraprolin (TTP; encoded by\n                    <jats:italic>Zfp36<\/jats:italic>\n                    ), which promotes degradation of mRNAs with AREs in their 3\u2032UTR. TTP accelerates the decay of its target transcripts, many of which encode proinflammatory mediators that promote tumorigenesis. TTP underexpression has been reported in multiple cancer types. Oral squamous cell carcinoma is an aggressive disease characterized by high morbidity and few therapeutic options. The role of TTP has not been studied in oral epithelium homeostasis nor in its carcinogenesis. Herein, using tissue-specific TTP knockout mice (TTP-KO), we show that TTP expression is relevant for oral epithelium homeostasis. TTP-KO mice developed dysplastic lesions in the tongue along with inflammatory infiltrates in the connective tissue. Analysis of the inflammatory infiltrate revealed the presence of mast cells (MCs), CD45+ cells, and CD11b+ cells, with the MCs being the most abundant cell type and associated with cyclooxygenase-2 expression. Recruitment of MCs was dependent on tumor necrosis factor\u2013\u03b1 (TNF\u03b1) upon TTP ablation in the tongue. Although the infiltration of MCs was dependent on TNF\u03b1 activity, this did not affect the development of tongue dysplasia. We analyzed the status of the NF-\u03baB pathway, finding its activation. In addition, we demonstrate that K-ras activation combined with\n                    <jats:italic>Zfp36<\/jats:italic>\n                    deletion leads to the rapid onset of the oral tongue phenotype and significantly reduces mouse survival. Our results support the notion that TTP expression protects against oral carcinogenesis, regulates the inflammatory infiltrate, and maintains the epithelial microenvironment, potentially serving as a barrier to tumorigenesis.\n                  <\/jats:p>","DOI":"10.1177\/00220345251316828","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T01:07:59Z","timestamp":1741828079000},"page":"795-805","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["TTP as Tumor Suppressor and Inflammatory Regulator in Oral Carcinogenesis"],"prefix":"10.1177","volume":"104","author":[{"given":"D.M.","family":"Ferri","sequence":"first","affiliation":[{"name":"Instituto de Fisiolog\u00eda, Biolog\u00eda Molecular y Neurociencias (IFIBYNE-UBA-CONICET), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6284-7925","authenticated-orcid":false,"given":"M.","family":"Ayre","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda, Biolog\u00eda Molecular y Neurociencias (IFIBYNE-UBA-CONICET), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ariza Bare\u00f1o","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Instituto de Oncolog\u00eda \u00c1ngel H. Roffo, \u00c1rea Investigaci\u00f3n, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Stedile","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda, Biolog\u00eda Molecular y Neurociencias (IFIBYNE-UBA-CONICET), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.V.","family":"DiGaudio","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda, Biolog\u00eda Molecular y Neurociencias (IFIBYNE-UBA-CONICET), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Fernandez Ugazio","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda, Hospital Zubizarreta, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.C.","family":"Kordon","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda, Biolog\u00eda Molecular y Neurociencias (IFIBYNE-UBA-CONICET), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Buenos Aires, Argentina"},{"name":"Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Qu\u00edmica Biol\u00f3gica, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"Blackshear","sequence":"additional","affiliation":[{"name":"Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA"},{"name":"Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Urtreger","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Instituto de Oncolog\u00eda \u00c1ngel H. Roffo, \u00c1rea Investigaci\u00f3n, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8299-0989","authenticated-orcid":false,"given":"A.R.","family":"Raimondi","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda, Biolog\u00eda Molecular y Neurociencias (IFIBYNE-UBA-CONICET), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Buenos Aires, Argentina"},{"name":"Universidad de Buenos Aires, Facultad de Odontolog\u00eda, C\u00e1tedra de Anatom\u00eda Patol\u00f3gica, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgt349"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.92979"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.140669"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.06.008"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20437"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0300945"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2013.02.003"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2007.04.011"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp127"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-14-0102"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3611"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27022"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26229"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23904"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(01)00350-X"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-3110"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00224-3"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2011.93"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11111754"},{"issue":"5","key":"e_1_3_3_22_1","first-page":"1093","article-title":"Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma","volume":"56","author":"Kurihara-Shimomura M","year":"2020","unstructured":"Kurihara-Shimomura M, Sasahira T, Shimomura H, Bosserhoff AK, Kirita T. 2020. Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma. 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