{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:18:43Z","timestamp":1787836723789,"version":"build-2784847793"},"reference-count":34,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Sichuan Science and Technology Program","award":["2023YFQ0014"],"award-info":[{"award-number":["2023YFQ0014"]}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2023NSFSC1504"],"award-info":[{"award-number":["2023NSFSC1504"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270970, 82470967"],"award-info":[{"award-number":["82270970, 82470967"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>\n                    Tooth caries is a prevalent chronic oral disease with microorganisms as the initiating factor and carbohydrates as the key environmental factor. Clinical antimicrobial therapies rely mainly on broad-spectrum antibiotics, which usually increase the risk of bacterial resistance. Recently, phototherapy has shown powerful antibacterial effects, although it cannot effectively eliminate cariogenic microenvironments and the antibacterial effect is not sustained after the light is removed. Here, we developed novel bioheterojunctions (bio-HJs) comprising MXene\/Ag\n                    <jats:sub>3<\/jats:sub>\n                    PO\n                    <jats:sub>4<\/jats:sub>\n                    (MX\/AgP) and glucose oxidase (GOx), denoted MX\/AgP-GOx, aiming at both the chemical and biological components of dental plaque biofilm. The bio-HJs decomposed the glucose rich in the cariogenic environment through GOx while providing abundant H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    for subsequent Fenton reaction. Under near-infrared (NIR) light, the bio-HJs produced hyperthermia and generated large amounts of reactive oxygen species based on the above H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , exerting powerful phototherapy properties (log reduction: 1.45 log 10 CFU\/mL). It is worth noting that MX\/AgP-GOx still exerted antibacterial effects in the dark via Ag\n                    <jats:sup>+<\/jats:sup>\n                    bactericidal effects, Ag\n                    <jats:sup>0<\/jats:sup>\n                    NPs catalytic activity, and GOx-mediated glucose depletion (log reduction: 0.39 log 10 CFU\/mL), ensuring a sustained anticaries effect after the removal of NIR light. In addition, the rat caries model revealed that MX\/AgP-GOx significantly reduced enamel mineral loss and had good biocompatibility. This study constructed efficacy-cascade bio-HJs targeting the sugar-rich cariogenic microenvironment, which promotes subsequent photodynamic therapy and combines photothermal and metal ion synergistic antibacterial means to continuously and effectively eliminate biofilm and prevent the occurrence and development of tooth caries.\n                  <\/jats:p>","DOI":"10.1177\/00220345251329334","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T07:51:00Z","timestamp":1746172260000},"page":"1095-1104","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Bioheterojunctions Prevent Tooth Caries via Cascade Antibacterial Strategy"],"prefix":"10.1177","volume":"104","author":[{"given":"J.","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China"},{"name":"Department of Geriatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China"},{"name":"Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China"},{"name":"Department of Geriatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2701-5179","authenticated-orcid":false,"given":"J.","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China"},{"name":"Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Yan","sequence":"additional","affiliation":[{"name":"Second Clinical Division, Peking University School and Hospital of Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China"},{"name":"Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7121-9817","authenticated-orcid":false,"given":"K.","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China"},{"name":"Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10122413"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c09454"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-020-0124-3"},{"key":"e_1_3_2_5_1","doi-asserted-by":"crossref","unstructured":"Cheng X Xu X Zhou X Ning J. 2024. 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