{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:31:15Z","timestamp":1793413875162,"version":"4.5.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE011111"],"award-info":[{"award-number":["DE011111"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE024509"],"award-info":[{"award-number":["DE024509"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    Enrichment of the oral microorganism\n                    <jats:italic>Filifactor alocis<\/jats:italic>\n                    is strongly associated with the progression of periodontitis. However,\n                    <jats:italic>F. alocis<\/jats:italic>\n                    is part of a complex dysbiotic microbial community, and the organism\u2019s direct pathogenic potential remains uncharacterized. Using the oral gavage model of experimental periodontitis, we revealed that\n                    <jats:italic>F. alocis<\/jats:italic>\n                    promotes alveolar bone loss, as well as significant overexpression of proinflammatory markers associated with osteoclastogenesis and inflammation in oral tissues. Interestingly, despite colonizing in low abundance,\n                    <jats:italic>F. alocis<\/jats:italic>\n                    infection promoted the perturbation of the homeostatic oral microbial community toward a dysbiotic state. Systemically, high levels of proinflammatory cytokines, chemokines, and antibody titers against\n                    <jats:italic>F. alocis<\/jats:italic>\n                    were detected in the sera of infected animals. Germ-free mice or TLR2-deficient mice did not develop alveolar bone loss when infected with\n                    <jats:italic>F. alocis<\/jats:italic>\n                    , demonstrating that the commensal microbial community and the presence of TLR2 are required for\n                    <jats:italic>F. alocis<\/jats:italic>\n                    to display its pathogenic potential. These findings identify\n                    <jats:italic>F. alocis<\/jats:italic>\n                    as an oral pathogen that can disrupt the homeostatic relationship between the host and the oral microbiome, causing inflammation and alveolar bone resorption. Our findings provide novel insights into the pathogenic potential of\n                    <jats:italic>F. alocis<\/jats:italic>\n                    in periodontitis.\n                  <\/jats:p>","DOI":"10.1177\/00220345251331959","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T03:12:12Z","timestamp":1750821132000},"page":"1248-1256","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>Filifactor alocis<\/i>\n                    Pathogenicity Requires TLR2 and the Oral Microbiome"],"prefix":"10.1177","volume":"104","author":[{"given":"A.","family":"Vashishta","sequence":"first","affiliation":[{"name":"Department of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral Biology and UB Microbiome Center, School of Dental Medicine, State University of New York at Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY, 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