{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:13:59Z","timestamp":1793276039839,"version":"4.5.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>Materials informatics (MI) has gained attention as a data-driven approach to accelerating material optimization in several fields. By leveraging computational methods, recent advancements in artificial intelligence, and large datasets, MI is poised to significantly accelerate the development of various materials. This approach drives innovative solutions, offers new insights into composition\u2013property relationships, and potentially redefines the standards for material testing and selection. Consequently, MI has become a powerful alternative to traditional experimentation, offering more systematic and efficient pathways for materials innovation. Despite its success in other domains, only a handful of studies have used MI in dental materials research, which has long relied on iterative, labor-intensive empirical testing to make incremental improvements. This narrative review summarizes the fundamental principles of MI while showcasing its emerging role in dental materials research. We also discuss advantages of MI compared with traditional pipelines; current limitations, such as data scarcity and the challenges of translating in vitro findings to clinical outcomes; and future perspectives.<\/jats:p>","DOI":"10.1177\/00220345251343610","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:19:24Z","timestamp":1751242764000},"page":"1165-1170","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Materials Informatics Opens the Door for Dental Materials Development"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4661-8821","authenticated-orcid":false,"given":"S.","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Dental Biomaterials, Graduate School of Dentistry, The University of Osaka, Suita, Osaka, Japan"},{"name":"Joint Research Laboratory of Advanced Functional Materials Science, Graduate School of Dentistry, The University of Osaka, Suita, Osaka, Japan"},{"name":"AI Research Unit, Graduate School of Dentistry, The University of Osaka, Suita, Osaka, Japan"},{"name":"Department of Conservative Dentistry and Periodontology, LMU University Hospital, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dental Biomaterials, Graduate School of Dentistry, The University of Osaka, Suita, Osaka, Japan"},{"name":"Joint Research Laboratory of Advanced Functional Materials Science, Graduate School of Dentistry, The University of Osaka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6260-9992","authenticated-orcid":false,"given":"A.","family":"Tichy","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology, LMU University Hospital, LMU Munich, Munich, Germany"},{"name":"Institute of Dental Medicine, First Faculty of Medicine of the Charles University and General University Hospital in Prague, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1223-1669","authenticated-orcid":false,"given":"F.","family":"Schwendicke","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology, LMU University Hospital, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Imazato","sequence":"additional","affiliation":[{"name":"Department of Dental Biomaterials, Graduate School of Dentistry, The University of Osaka, Suita, Osaka, Japan"},{"name":"Joint Research Laboratory of Advanced Functional Materials Science, Graduate School of Dentistry, The University of Osaka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,29]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jerd.12876"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2023.106245"},{"key":"e_1_3_3_4_1","unstructured":"Anusavice KJ. 2003. Phillips\u2019 science of dental materials. 11th ed. St. Louis (MO): Saunders."},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/489049a"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2442-2"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345221145673"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345231198185"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2021.109495"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax1566"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2015.07.005"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2010.10.020"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/489208b"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0307-8"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40496-023-00344-1"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2017.04.013"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c00461"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.9b00995"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202201559"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14539"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345221089251"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.0c01153"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00180-020-00999-9"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c05145"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.2c01298"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40537-021-00518-7"},{"key":"e_1_3_3_27_1","doi-asserted-by":"crossref","unstructured":"Opdam NJM Sande FHvd Bronkhorst E Cenci MS Bottenberg P Pallesen U Gaengler P Lindberg A Huysmans MCDNJM van Dijken JW et al. 2014. Longevity of posterior composite restorations: a systematic review and meta-analysis. J Dent Res. 93(10):943\u2013949.","DOI":"10.1177\/0022034514544217"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oor.2024.100697"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aat5559"},{"key":"e_1_3_3_30_1","article-title":"Materials informatics: knowledge acquisition for materials design","volume":"226","author":"Rodgers JR","year":"2003","unstructured":"Rodgers JR. 2003. Materials informatics: knowledge acquisition for materials design. Abstr Pap Am Chem Soc. 226:U302\u2013U303.","journal-title":"Abstr Pap Am Chem Soc"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514553976"},{"key":"e_1_3_3_32_1","first-page":"1","volume-title":"Craig\u2019s restorative dental materials","author":"Sakaguchi R","year":"2019","unstructured":"Sakaguchi R, Ferracane J, Powers J. 2019. Chapter 1\u2014role and significance of restorative dental materials. In: Craig\u2019s restorative dental materials. 14th ed. Philadelphia (PA): Elsevier. p. 1\u20134.","edition":"14"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00927"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1109\/JPROC.2015.2494218"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2023.2187671"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b02717"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17266-6"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj5505"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345231175868"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345251343610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00220345251343610","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345251343610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:09:27Z","timestamp":1777496967000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00220345251343610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,29]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/00220345251343610"],"URL":"https:\/\/doi.org\/10.1177\/00220345251343610","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,29]]}}}