{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T13:01:48Z","timestamp":1777813308968,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T00:00:00Z","timestamp":1753574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T00:00:00Z","timestamp":1753574400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    Rare disorders related to tight junction (TJ) proteins have been associated with amelogenesis imperfecta. Pathogenic variants of\n                    <jats:italic toggle=\"yes\">CLDN10<\/jats:italic>\n                    , encoding claudin-10b, a cation transport pore, cause the autosomal recessive HELIX syndrome (Hypohidrosis, Electrolyte imbalance, hypoLacrymia, Ichthyosis, Xerostomia). Patients exhibit salivary dysfunction and rapid enamel wear after tooth eruption. Since C\n                    <jats:italic toggle=\"yes\">ldn10<\/jats:italic>\n                    is expressed in the dental epithelium, this study explores the role of claudin-10b in amelogenesis. We analyzed amelogenesis in constitutive and conditional\n                    <jats:italic toggle=\"yes\">Cldn10<\/jats:italic>\n                    knockout (KO) murine models, comparing the findings to human HELIX enamel. First, analysis of constitutive\n                    <jats:italic toggle=\"yes\">Cldn10<\/jats:italic>\n                    knockout (KO) mice, which die within a few hours after birth, showed that claudin-10 is present at the plasma membrane of the stratum intermedium but not at the TJs during the secretory stage. Its absence altered gene expression related to ion transport and pH control, although without major disturbance in cell polarization or enamel matrix synthesis. Examination of later stages of amelogenesis in epithelium-targeted conditional\n                    <jats:italic toggle=\"yes\">Cldn10<\/jats:italic>\n                    KO mice showed that claudin-10 is present in the papillary layer at the maturation stage. In its absence, the pH of the enamel matrix was more basic during early maturation, suggesting that claudin-10 determines enamel matrix pH. However, at later stage of the maturation process, the pH was corrected and the resulting enamel did not show major structural or elemental alterations. These later findings were confirmed by exploring the enamel of\n                    <jats:italic toggle=\"yes\">Cldn10<\/jats:italic>\n                    KO transplanted tooth germs, which have developed in a controlled mineral environment. Nevertheless, higher contents of aluminum were detected in the enamel of transplanted germs and in human HELIX enamel, suggesting that claudin-10 deficiency may lead to a loss of enamel organ integrity. These data suggest that while salivary dysfunction is the main cause of enamel wear in HELIX, claudin-10 plays a direct role in amelogenesis by determining pH and enamel organ integrity.\n                  <\/jats:p>","DOI":"10.1177\/00220345251349109","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T05:49:07Z","timestamp":1753681747000},"page":"385-395","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Absence of Claudin-10 in the Enamel Organ Alters Its Integrity"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2848-242X","authenticated-orcid":false,"given":"T.N.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U1333 Sant\u00e9 Orale, et Plateforme Imagerie du Vivant (PIV), FHU-DDS-net, IHMOA, Dental School, Montrouge, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ribes","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U1333 Sant\u00e9 Orale, et Plateforme Imagerie du Vivant (PIV), FHU-DDS-net, IHMOA, Dental School, Montrouge, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0447-9616","authenticated-orcid":false,"given":"C.","family":"Andrique","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U1333 Sant\u00e9 Orale, et Plateforme Imagerie du Vivant (PIV), FHU-DDS-net, IHMOA, Dental School, Montrouge, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Requin","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, CNRS, IBDM-UMR7288, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6611-4380","authenticated-orcid":false,"given":"J.","family":"Bouchet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U1333 Sant\u00e9 Orale, et Plateforme Imagerie du Vivant (PIV), FHU-DDS-net, IHMOA, Dental School, Montrouge, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Obtel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U1333 Sant\u00e9 Orale, et Plateforme Imagerie du Vivant (PIV), FHU-DDS-net, IHMOA, Dental School, Montrouge, France"},{"name":"AP-HP Services de m\u00e9decine bucco-dentaire, H\u00f4pitaux Universitaires Bretonneau (CRMR phosphore et calcium, fili\u00e8re OSCAR et ERN BOND), and Henri Mondor and Charles Foix (fili\u00e8re TETECOU et ERN CRANIO), FHU DDS-net, Ile de France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Slimani","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U1333 Sant\u00e9 Orale, et Plateforme Imagerie du Vivant (PIV), FHU-DDS-net, IHMOA, Dental School, Montrouge, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Brouilly","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, CNRS, IBDM-UMR7288, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Torrens","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U1333 Sant\u00e9 Orale, et Plateforme Imagerie du Vivant (PIV), FHU-DDS-net, IHMOA, Dental School, Montrouge, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5069-0730","authenticated-orcid":false,"given":"T.","family":"Guilbert","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Morawietz","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Microstructure of Materials and Systems IMWS, Walter-Huelse-Stra\u00dfe 1, 06120 Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kiesow","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Microstructure of Materials and Systems IMWS, Walter-Huelse-Stra\u00dfe 1, 06120 Halle, 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