{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:13:04Z","timestamp":1792109584621,"version":"4.4.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Minnesota Craniofacial Research Training (MinnCResT) Program","award":["R90 DE 023058"],"award-info":[{"award-number":["R90 DE 023058"]}]},{"DOI":"10.13039\/100000002","name":"The National Institutes of Health","doi-asserted-by":"crossref","award":["1R01DE030095-01A1"],"award-info":[{"award-number":["1R01DE030095-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"The National Institutes of Health","doi-asserted-by":"crossref","award":["1R21DE029601-01A1"],"award-info":[{"award-number":["1R21DE029601-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"The National Institutes of Health","doi-asserted-by":"crossref","award":["R00DE032747"],"award-info":[{"award-number":["R00DE032747"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    Dysbiotic subgingival biofilms initiate periodontitis, while the consequential destruction of periodontal tissues results from a dysregulated local immune response. Interstitial CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells play a crucial role in orchestrating periodontal inflammation. Upon activation, CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells express CD69 receptors, which can influence their migration patterns, phenotype, and function during inflammation. Here, we report that in the absence of CD69, memory CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells (mCD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells) derived from gingival and cervical lymph nodes (cLNs) display an increased proinflammatory phenotype. Following in vitro activation, negative-selected mCD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells from cLNs of CD69\n                    <jats:sup>KO<\/jats:sup>\n                    mice showed enhanced expression of interleukin (IL)\u201317A (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.0043) and interferon-\u03b3 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.0479). Although comparable to untreated wild-type (WT) mice in the absence of disease, CD69-deficient mice showed augmented alveolar bone loss and a greater interstitial inflammatory cell infiltrate after 7\u2009d of ligature-induced experimental periodontitis. Furthermore, gingival CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells derived from mice lacking CD69 produced significantly higher levels of IL-17A compared with WT animals. 16S rRNA gene sequencing and bioinformatics analyses of the subgingival microbiota associated with ligatures indicated that the absence of CD69 in the host significantly shaped the composition of the periodontitis-associated biofilm. Therefore, our data suggest that CD69 receptors play a regulatory role in both the cellular and microbial microenvironments associated with periodontitis.\n                  <\/jats:p>","DOI":"10.1177\/00220345251383827","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T05:40:26Z","timestamp":1764222026000},"page":"930-937","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["CD69 Regulates Gingival Inflammation and Microbiome in Periodontitis"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8623-8543","authenticated-orcid":false,"given":"F.M.","family":"Saavedra","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA"},{"name":"Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA"},{"name":"Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.D.","family":"Bittner-Eddy","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.F.","family":"Johnstone","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Stolley","sequence":"additional","affiliation":[{"name":"Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA"},{"name":"Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH, USA"},{"name":"Center for Immunology, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.W.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA"},{"name":"Department of Microbiology and Immunology, Medical School, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.","family":"Herzberg","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Costalonga","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2013.05.002"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2936"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(94)90055-8"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.123299"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01398"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12002"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646837"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.952820"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12709"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat0797"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140520"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12436"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aau4594"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3601"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102453"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000171"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.742925"},{"key":"e_1_3_2_19_1","first-page":"334","article-title":"Unraveling CD69 signaling pathways, ligands and laterally associated molecules","volume":"22","author":"Jim\u00e9nez-Fern\u00e1ndez M","year":"2023","unstructured":"Jim\u00e9nez-Fern\u00e1ndez M, de la Fuente H, Mart\u00edn P, Cibri\u00e1n D, S\u00e1nchez-Madrid F. 2023. Unraveling CD69 signaling pathways, ligands and laterally associated molecules. EXCLI J. 22:334\u2013351.","journal-title":"EXCLI J"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00122-21"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-273987"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12091"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0674"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00456-10"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.709438"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00363.x"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mucimm.2025.02.003"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319112"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118539109"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04606"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221853"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.625034"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2010.62"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900052"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0927-9"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345251383827","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00220345251383827","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345251383827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:02:20Z","timestamp":1782140540000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00220345251383827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/00220345251383827"],"URL":"https:\/\/doi.org\/10.1177\/00220345251383827","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]}}}